PRKACB Antibody

中文名稱：

PRKACB兔多克隆抗體
貨號：

CSB-PA018689LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: PRKACB antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 47, 40, 42, 30, 37 kDa
Observed band size: 41, 47 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018689LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018689LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA018689LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PRKACB Polyclonal antibody
Uniprot No.：

P22694
基因名：

PRKACB
別名：

cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody; cAMP-dependent protein kinase catalytic subunit beta antibody; KAPCB_HUMAN antibody; PKA C beta antibody; PKA C-beta antibody; PKACB antibody; Prkacb antibody; protein kinase A catalytic subunit beta antibody; Protein kinase cAMP dependent catalytic beta antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human cAMP-dependent protein kinase catalytic subunit beta protein (2-53AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PRKACB Antibody (CSB-PA018689LA01HU)，的標記方式是Non-conjugated。對于PRKACB Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018689LB01HU	PRKACB Antibody, HRP conjugated	ELISA
FITC	CSB-PA018689LC01HU	PRKACB Antibody, FITC conjugated
Biotin	CSB-PA018689LD01HU	PRKACB Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
基因功能參考文獻：
1. Cbeta2 subunit of protein kinase A mRNA was up-regulated in prostate cancer and low expression of Cbeta2 mRNA in prostate cancer biopsies correlated with poor survival. PMID: 27838142
2. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
3. The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation. PMID: 24294386
4. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
5. activated by podophyllotoxin PMID: 20033853
6. PGE(2)-induced CYP1B1 expression is mediated by ligand-independent activation of the ERalpha pathway as a result of the activation of ERK, Akt, and PKA in breast cancer cells. PMID: 20093341
7. Data show that PI3K activation and PIP3 production lead to recruitment of the PKB/beta-arrestin/PDE4 complex to the membrane via the PKB PH domain, resulting in degradation of the TCR-induced cAMP pool and allowing full T-cell activation to proceed. PMID: 20086095
8. c-MYC induces the activity of protein kinase A by inducing the transcription of the gene encoding the PKA catalytic subunit beta in multiple tissues, independent of cell proliferation by direct binding of c-MYC to promoter sequences. PMID: 12420224
9. Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP-dependent protein kinase (PKACbeta) as a p75 neurotrophin receptor(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304. PMID: 12682012
10. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta. PMID: 14744463
11. there is a PKA-Cbeta-mediated inhibitory mechanism of p73 function PMID: 15723830
12. Murine lymphoid tissues express a protein that is a homologue of human protein kinase c subunit beta2 PMID: 16889664
13. In conclusion, it seems that the Cbeta isoforms of PKA play different roles in proliferation and differentiation and could therefore be potential markers for prostate cancer progression. PMID: 16949795
14. Data provide the first evidence that Protein kinase C -beta play pivotal role in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells. PMID: 17549442
15. Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. PMID: 18499756
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亞細胞定位：

Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
組織特異性：

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
數據庫鏈接：

HGNC: 9381

OMIM: 176892

KEGG: hsa:5567

STRING: 9606.ENSP00000359719

UniGene: Hs.487325

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