PPT1 Antibody

中文名稱：

PPT1兔多克隆抗體
貨號：

CSB-PA018587LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate
All lanes: PPT1 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35, 24 kDa
Observed band size: 35 kDa

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA018587LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPT1 Polyclonal antibody
Uniprot No.：

P50897
基因名：

PPT1
別名：

Ceroid palmitoyl palmitoyl protein thioesterase 1 antibody; CLN1 antibody; EC 3.1.2.22 antibody; INCL antibody; Palmitoyl protein hydrolase 1 antibody; Palmitoyl protein thioesterase 1 antibody; Palmitoyl-protein hydrolase 1 antibody; Palmitoyl-protein thioesterase 1 antibody; PPT antibody; PPT-1 antibody; PPT1 antibody; PPT1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Palmitoyl-protein thioesterase 1 protein (100-258AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PPT1 Antibody (CSB-PA018587LA01HU)，的標記方式是Non-conjugated。對于PPT1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018587LB01HU	PPT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018587LC01HU	PPT1 Antibody, FITC conjugated
Biotin	CSB-PA018587LD01HU	PPT1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
基因功能參考文獻：
1. Targeting PPT1 blocks mTOR signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy. PMID: 28899863
2. the combination of elevated glycolysis and deficient MRPL13 activity was closely linked to CLN1-mediated tumor activity in human hepatoma cells PMID: 28978646
3. Proteomics analysis on isolated cilia revealed 660 proteins, which differed in their abundance levels between wild type and Ppt1 knock out. PMID: 28334871
4. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins. PMID: 26731412
5. analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells PMID: 25865307
6. Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article] PMID: 25233404
7. Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line. PMID: 24083319
8. This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis was not previously reported. PMID: 22520356
9. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis patients. PMID: 21704547
10. Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes. PMID: 19793631
11. mutated in neuronal ceroid lipofuscinosis PMID: 12025857
12. The clinical, biochemical, and molecular genetic aspects of lysosomal storage disorders are discussed in this review PMID: 12125808
13. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. PMID: 12855696
14. there is a close correlation between CLN2 and CLN1 expression and colorectal carcinoma progression and metastasis and suggest that they may be potential molecular targets PMID: 16518810
15. Results show that PPT1-deficiency causes a defect in fluid-phase and receptor-mediated endocytosis. PMID: 16542649
16. ER stress due to PPT1-deficiency increases ROS and disrupts calcium homeostasis activating caspase-9 and caspase-9 activation mediates caspase-3 activation and apoptosis contributing to rapid neurodegeneration in INCL. PMID: 16571600
17. Adult neuronal ceroid lipofuscinosis caused by deficiency in palmitoyl protein thioesterase 1. PMID: 17261688
18. Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals in humans and mice PMID: 18704195
19. study presents clinical and diagnostic investigations in six children with variant late infantile neuronal ceroid lipofuscinosis and mutations in CLN1 including a new large-scale deletion on one allele PMID: 19302939
20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
21. The function of PPT1 is to hydrolyze long-chain fatty acids from cysteine residues of fatty acylated proteins in the lysosome. PMID: 8816748
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相關疾病：

Ceroid lipofuscinosis, neuronal, 1 (CLN1)
亞細胞定位：

Lysosome. Secreted.
蛋白家族：

Palmitoyl-protein thioesterase family
數據庫鏈接：

HGNC: 9325

OMIM: 256730

KEGG: hsa:5538

STRING: 9606.ENSP00000394863

UniGene: Hs.3873

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