PPRC1 Antibody
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中文名稱：PPRC1兔多克隆抗體
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貨號：CSB-PA008323
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：PPRC1
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別名：PPRC1 antibody; KIAA0595 antibody; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 antibody; PGC-1-related coactivator antibody; PRC antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the C-terminal region of Human PRC.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.
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基因功能參考文獻：
- PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. PMID: 27789709
- PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity PMID: 23954632
- A general role for PRC in the adaptive response to cellular dysfunction. PMID: 23364789
- PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle PMID: 19956726
- overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma PMID: 14550271
- PGC-1 has a role in regulating gluconeogenic genes along with HNF-4alpha and SREBP-1 PMID: 14722127
- This review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. PMID: 16511594
- Upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation. PMID: 17341490
- These results revealed that bile acid inhibits the promoter activity of PGC-1 in an SHP-dependent manner. PMID: 17390079
- Activation of the SIRT1/PGC-1 pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review. PMID: 17937892
- The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
- support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth PMID: 19036724
- Coordinate regulation of nucleus-encoded mitochondrial transcription factors by NRFs and PGC-1 family coactivators is essential to the control of mitochondrial biogenesis PMID: 15684387
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亞細胞定位：Nucleus.
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組織特異性：Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.
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數據庫鏈接：
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