PPP3CC Antibody

說明書

中文名稱：

PPP3CC兔多克隆抗體
貨號：

CSB-PA018574ESR1HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody at 10μg/ml
Lane 1: Rat brain tissue
Lane 2: MCF-7 whole cell lysate
Lane 3: Rat skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 59, 58, 60 kDa
Observed band size: 59 kDa

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA018574ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA018574ESR1HU at dilution of 1:100
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PPP3CC Polyclonal antibody
Uniprot No.：

P48454
基因名：

PPP3CC
別名：

calcineurin A gamma antibody; CALCINEURIN A3 antibody; Calcineurin antibody; Calcineurin testis specific catalytic subunit antibody; Calmodulin dependent calcineurin A subunit gamma isoform antibody; Calmodulin-dependent calcineurin A subunit gamma isoform antibody; CALNA3 antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA3 antibody; pp2b gamma Antibody antibody; PP2BC_HUMAN antibody; PP2Bgamma Antibody antibody; PPP3CC antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform (calcineurin A gamma) antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody; testis-specific catalytic subunit antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform protein (373-512AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
基因功能參考文獻：
1. PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk. PMID: 29275364
2. These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas. PMID: 29294030
3. The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury. PMID: 27225880
4. Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons. PMID: 26627835
5. The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation. PMID: 24709691
6. protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway PMID: 23747857
7. study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender PMID: 23497497
8. This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
9. results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis PMID: 12851458
10. Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia. PMID: 15820226
11. PPP3CC may not play a major role in Japanese schizophrenia PMID: 15843870
12. The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia. PMID: 17339875
13. The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia. PMID: 17895921
14. No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls PMID: 18343007
15. Data suggest that PPP3CC does not elevate the risk of methamphetamine-use disorder in the Japanese population. PMID: 18991849
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蛋白家族：

PPP phosphatase family, PP-2B subfamily
組織特異性：

Testis.
數(shù)據(jù)庫鏈接：

HGNC: 9316

OMIM: 114107

KEGG: hsa:5533

STRING: 9606.ENSP00000240139

UniGene: Hs.731683

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