PPP3CB Antibody

說明書

中文名稱：

PPP3CB兔多克隆抗體
貨號：

CSB-PA018573GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P16298
基因名：

PPP3CB
別名：

Calcineurin A beta antibody; Calcineurin A2 antibody; Calcineurin B; formerly antibody; Calmodulin dependent calcineurin A subunit beta isoform antibody; Calmodulin-dependent calcineurin A subunit beta isoform antibody; CALNA 2 antibody; CALNA2 antibody; CALNB antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA2 antibody; CnAbeta antibody; PP2BB_HUMAN antibody; PP2Bbeta antibody; PPP3CB antibody; Protein phosphatase 2B; catalytic subunit; beta isoform; formerly antibody; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isoform antibody; Protein phosphatase 3 catalytic subunit beta isozyme antibody; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human PPP3CB
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
基因功能參考文獻(xiàn)：
1. The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients PMID: 27907007
2. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. PMID: 21531385
3. The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect. PMID: 21664352
4. A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. PMID: 21423799
5. [review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta. PMID: 19925438
6. calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate PMID: 15514034
7. depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated PMID: 15557343
8. Calcineurin A beta expression is an additional means of regulating calcineurin activity in the heart. PMID: 16024800
9. Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus. PMID: 18034994
10. We describe a case of Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation. PMID: 18458866
11. TAK1-TAB1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1. PMID: 19136967
12. calcineurin is inhibited by cyclosporine A, which then exerts multiple effects on human melanoma cell lines HT168 and WM35 PMID: 19287956
13. calcineurin can dephosphorylate GSK-3beta at Ser-9 and form a stable complex with GSK-3beta, suggesting the possibility that calcineurin regulates the dephosphorylation and activation of GSK-3betain vivo PMID: 19659461
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

PPP phosphatase family, PP-2B subfamily
數(shù)據(jù)庫鏈接：

HGNC: 9315

OMIM: 114106

KEGG: hsa:5532

STRING: 9606.ENSP00000378306

UniGene: Hs.500067

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