PPP2R2B Antibody

說明書

中文名稱：

PPP2R2B兔多克隆抗體
貨號：

CSB-PA168178
規格：

￥2024
圖片：
Western blot analysis of extracts from HeLa cells, using PPP2R2B antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP2R2B Polyclonal antibody
Uniprot No.：

Q00005
基因名：

PPP2R2B
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human PPP2R2B.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
基因功能參考文獻：
1. Dephosphorylation and total levels of beta-catenin were dependent on PR55beta in an adenoid cystic carcinoma tumor cell line. PMID: 29275362
2. New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis. PMID: 27864267
3. CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients. PMID: 27350687
4. Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression. PMID: 26653855
5. investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30 PMID: 25634432
6. IER5 functions as a positive feedback regulator of HSF1 and that this process involves PP2A/B55 and HSF1 dephosphorylation. PMID: 25816751
7. Bcl-2 phosphorylation at Ser70 by selective tyrosine nitration of PP2A-B56delta stabilizes its antiapoptotic activity PMID: 25082878
8. Inactivation of protein-phosphatase 2A causing hyperphosphorylation of paraprotein targets in monoclonal gammopathy of undetermined significance, multiple myeloma and Waldenstrom's macroglobulinemia is due to an exchange of its regulatory subunits PMID: 24676687
9. We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194. Ensa/ARPP19 dephosphorylation is mediated by the RNA PMID: 24391510
10. PP2A-B55beta promotes cyclin E1 overexpression by antagonizing its degradation and its inhibition could represent a therapeutic mechanism for abrogating cyclin E1 function in cancers PMID: 24509904
11. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. PMID: 24157919
12. Differential autophagic neuronal cell death under stress is determined by the cytoplasmic and mitochondrial-specific PPP2R2B isoforms. PMID: 23381641
13. Single nucleotide polymorphisms in PPP2R2B is associated with drug response in breast cancer. PMID: 23034890
14. Data indicate that PPP2R2B gene product PP2A/Bbeta2 activates the mitochondrial fission enzyme dynamin-related protein 1 (Drp1) by dephosphorylating Ser656. PMID: 22583914
15. This study suggested that PPP2R2B CAG expansion mutation might lead increase induction of Spinocerebellar ataxia type 12. PMID: 21827912
16. defective production of PP2A Bbeta upon IL-2 deprivation results in apoptosis resistance and longer survival of autoreactive T cells, in a subset of SLE patients PMID: 21746932
17. oxidative stress induced by mitochondrial dysfunction causes elevated expression of ppp2r2b and plays a causal role in SCA12; and reduction of ROS is a potential therapeutic intervention for this neuropathy PMID: 21471219
18. results indicate that the A variant of the rs319217 SNP of the PPP2R2B gene is a marker of better prognosis in breast cancer PMID: 20669227
19. CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for Alzheimer disease susceptibility in the Japanese population. PMID: 21029765
20. PPP2R2B, encoding the B55beta regulatory subunit of the PP2A complex, is epigenetically inactivated by DNA hypermethylation in colorectal cancer. PMID: 21075311
21. Autosomal dominant cerebellar ataxia mapping to 5q31-q33.1 has no CAG repeat expansion or other mutations of the PPP2R2B gene. PMID: 20937954
22. Quantitative methylation analysis identified ABCB1, FOXC1, PPP2R2B and PTEN as novel genes to be methylated in ductal carcinoma in situ. PMID: 20056007
23. The CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B expression. PMID: 20533062
24. We investigated methylation patterns in the promoter regions of ABCB1, ATM, BRCA1, CDH3, CDKN2A, CXCR4, ESR1, FBXW7, FOXC1, GSTP1, IGF2, HMLH1, PPP2R2B, and PTEN75 in well-described pre-treatment samples from locally advanced breast cancer PMID: 20338046
25. Cells with ectopically expressed PPP2R2B were shown predisposed to autophagy and oxidative stress induced cell death. PMID: 20017961
26. a novel ATM-dependent mechanism is regulating association of B55 subunits with nuclear PP2A in response to IR PMID: 11723136
27. Cyclin G recruits PP2A in order to modulate the phosphorylation of Mdm2 and thereby to regulate both Mdm2 and p53. PMID: 11983168
28. Phosphorylation of bestrophin is regulated by PP2A. PMID: 12058047
29. SCA12 triplet expansion rate in Italian ataxia patients PMID: 12140678
30. Analysis of CTA/CTG and CAG polymorphism in a Polish control group. PMID: 14960773
31. phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells PMID: 16109716
32. PP2A plays a positive rather than a negative role in the regulation of IKKbeta PMID: 16126728
33. analysis of a founder for SCA12 in the Indian population PMID: 16138911
34. We therefore propose that PP2A plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex. PMID: 16245300
35. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. PMID: 16286244
36. PP2A-mediated dephosphorylation of HSP27 and tau correlated with PP2A-induced preservation of endothelial cell cytoskeleton PMID: 16475161
37. Cyclin G2 may modulate the cell cycle and cellular division processes through modulation of PP2A and centrosomal associated activities. PMID: 17123511
38. The small t antigen (ST) of DNA tumor virus SV40 inhibits PP2A phosphatase activity through its N-terminal J domain. PMID: 17529992
39. results suggest that the PPP2R2B gene CAG repeat polymorphism may be functional and may, in part, play a role in conferring susceptibility to Alzheimer disease and essential tremor in Taiwan PMID: 18484086
40. Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit PMID: 18653458
41. Results suggest that Parkinsonism (PD) and multiple system atrophy (MSA) are not associated with spinocerebellar ataxia 12 (SCA12) and it is not necessary to screen SCA12 in PD and MSA patients. PMID: 18973067
42. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
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相關疾病：

Spinocerebellar ataxia 12 (SCA12)
亞細胞定位：

[Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Membrane.; [Isoform 2]: Cytoplasm. Mitochondrion. Mitochondrion outer membrane.
蛋白家族：

Phosphatase 2A regulatory subunit B family
組織特異性：

Brain.
數據庫鏈接：

HGNC: 9305

OMIM: 604325

KEGG: hsa:5521

STRING: 9606.ENSP00000336591

UniGene: Hs.627618

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