PPP2R2A Antibody, Biotin conjugated

說明書

中文名稱：

PPP2R2A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA018564LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP2R2A Polyclonal antibody
Uniprot No.：

P63151
基因名：

PPP2R2A
別名：

2ABA_HUMAN antibody; Alpha isoform of regulatory subunit B55 protein phosphatase 2 antibody; B55A antibody; B55ALPHA antibody; calcineurin antibody; PP2A subunit B B alpha isoform antibody; PP2A subunit B B55 alpha isoform antibody; PP2A subunit B isoform alpha antibody; PP2A subunit B isoform B55-alpha antibody; PP2A subunit B isoform PR55-alpha antibody; PP2A subunit B isoform R2-alpha antibody; PP2A subunit B PR55 alpha isoform antibody; PP2A subunit B R2 alpha isoform antibody; PPP2R2A antibody; PR52A antibody; PR55A antibody; Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) alpha isoform antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit B (PR52); alpha isoform antibody; Protein phosphatase 2 regulatory subunit B alpha antibody; Protein phosphatase 2 regulatory subunit B alpha isoform antibody; Protein phosphatase 2 regulatory subunit Balpha antibody; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform antibody; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform antibody; Testicular tissue protein Li 156 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform protein (2-149AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
基因功能參考文獻：
1. Data show that SAM Domain and HD Domain-Containing Protein 1 (SAMHD1) is specifically targeted by protein phosphatase 2 regulatory subunit Balpha protein (PP2A-B55alpha) holoenzymes during mitotic exit. PMID: 29884836
2. the data suggested that miR614 promoted cell proliferation and inhibited cell apoptosis of ovarian cancer (OC) cells by targeting PPP2R2A, and may therefore act as a potential target for OC therapy in the future. PMID: 29532877
3. these results provide a novel insight into the role of PP2A-B55alpha as a novel meiotic and embryonic competence factor at the onset of life. PMID: 28439046
4. we propose that the Smad4-Pitx2-PPP2R2A axis, a new signaling pathway, suppresses the pancreatic carcinogenesis PMID: 26848620
5. These data unravel B55alpha as a PHD2 substrate and highlight a role for PHD2-B55alpha in the response to nutrient deprivation. PMID: 28329677
6. results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT, ERK, and Wnt PMID: 26893480
7. miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells. PMID: 26800397
8. miR-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression. PMID: 26297546
9. Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 expression define a subgroup of luminal-like BC patients with a high risk of relapse and death. PMID: 25879784
10. overexpression of miR-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression. PMID: 26054685
11. miR-136 may play an important role during TGF-beta1-induced proliferation arrest by targeting PPP2R2A in keratinocytes. PMID: 25654102
12. Data suggest livers of biliary atresia subjects exhibit overexpression of MIR222 (microRNA 222); this appears to contribute to liver fibrosis (and in vitro cell proliferation) by targeting PPP2R2A (protein phosphatase 2A subunit B) and Akt signaling. PMID: 25238119
13. The suppression of B55alpha activates signaling pathways that could support leukemia cell survival. PMID: 24858343
14. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A PMID: 24244166
15. miR-136 promotes Erk1/2 phosphorylation through targeting PPP2R2A in NSCLC cells and suggest that it may serve as a therapeutic target in NSCLC therapy. PMID: 23959478
16. PPP2R2A status may serve as a marker to predict therapeutic efficacy to PARP inhibition. PMID: 23087057
17. Both B55alpha and nuclear forkhead box O1 protein (FOXO1) levels are increased under hyperglycemic conditions in transgenic db/db mouse islets, an animal model of type 2 diabetes. PMID: 22417654
18. These data demonstrate that B55alpha acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle. PMID: 21813648
19. Somatic deletion rather than germline sequence variants of PPP2R2A may play a more important role in prostate cancer susceptibility. PMID: 21872824
20. The interaction of human adenovirus E4orf4 with both Cdc55 and B55 involves residues within blades 1 and 2, a finding that is consistent with the idea that E4orf4 binding may block the dephosphorylation of at least some PP2A substrates. PMID: 21047956
21. cyclin G2 also associates with various PP2A B' regulatory subunits, as previously shown for cyclin G1 PMID: 11956189
22. CFTR is regulated by a direct interaction with the protein phosphatase 2A PMID: 16239222
23. PP2A ABalphaC and ABdeltaC holoenzymes function as positive regulators of Raf1-MEK1/2-ERK1/2 signaling by targeting Raf1 PMID: 16239230
24. hAR is a direct target of LEF-1/TCF transcriptional regulation in PCa cells; expression of the hAR protein is suppressed by a degradation pathway regulated by cross-talk of Wnt, Akt, and PP2A PMID: 16474850
25. Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1. PMID: 16580887
26. deregulation of CHEK2 and/or PPP2R2A is of pathogenetic importance in at least a subset of germ cell tumors PMID: 16790090
27. The scaffolding subunit exhibits considerable conformational flexibility, which is proposed to play an essential role in PP2A function. PMID: 17055435
28. PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation PMID: 17255109
29. Protein phosphatase 2A and separase form a complex regulated by separase autocleavage PMID: 17604273
30. the protein phosphatase 2A regulatory subunit alpha4 has a novel role in the regulation of cell spreading and migration PMID: 17693407
31. PP2A constitutively dephosphorylates the class IIa member HDAC7 to control its biological functions as a regulator of T cell apoptosis and endothelial cell functions. PMID: 18339811
32. Homozygous deletions in a number of biologically important genes were found in prostate cancer cell lines, including PPP2R2A and BNIP3L identified in this study. PMID: 18670647
33. These highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes. PMID: 18697906
34. The authors show that E4orf4 protein interacts uniquely with B55 family subunits and that cell killing increases with the level of E4orf4 expression. PMID: 19535438
35. The results suggest that PR55 alpha specifically regulates PP2A-mediated beta-catenin dephosphorylation and plays an essential role in Wnt signaling. PMID: 19556239
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蛋白家族：

Phosphatase 2A regulatory subunit B family
組織特異性：

Expressed in all tissues examined.
數據庫鏈接：

HGNC: 9304

OMIM: 604941

KEGG: hsa:5520

STRING: 9606.ENSP00000325074

UniGene: Hs.146339

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