PPP2R1B Antibody

說明書

中文名稱：

PPP2R1B兔多克隆抗體
貨號：

CSB-PA830420ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA830420ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA830420ESR2HU at dilution of 1:100

IHC image of CSB-PA830420ESR2HU diluted at 1:403 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PPP2R1B Polyclonal antibody
Uniprot No.：

P30154
基因名：

PPP2R1B
別名：

2AAB_HUMAN antibody; beta isoform of regulatory subunit A; protein phosphatase 2 antibody; PP2A A beta antibody; PP2A subunit A isoform PR65-beta antibody; PP2A subunit A isoform R1-beta antibody; PP2A; subunit A; PR65 beta isoform antibody; PP2A; subunit A; R1 beta isoform antibody; PPP2R1B antibody; PPP4R1 antibody; PR65B antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform antibody; Protein phosphatase 2; regulatory subunit A; beta antibody; Protein phosphatase 2; structural/regulatory subunit A; beta antibody; protein phosphatase 2; structural/regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform protein (402-601AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
基因功能參考文獻：
1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176
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蛋白家族：

Phosphatase 2A regulatory subunit A family
數據庫鏈接：

HGNC: 9303

OMIM: 603113

KEGG: hsa:5519

STRING: 9606.ENSP00000311344

UniGene: Hs.269128

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