PPP2R1A Antibody

說明書

中文名稱：

PPP2R1A兔多克隆抗體
貨號：

CSB-PA018562GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P30153
基因名：

PPP2R1A
別名：

2AAA_HUMAN antibody; 6330556D22Rik antibody; Alpha isoform of regulatory subunit A; protein phosphatase antibody; DKFZp470L0914 antibody; Medium tumor antigen-associated 61 kDa protein antibody; MGC128399 antibody; MGC786 antibody; MGC83000 antibody; MGC95083 antibody; PP2A Aalpha antibody; PP2A antibody; PP2A subunit A isoform PR65-alpha antibody; PP2A subunit A isoform R1-alpha antibody; PP2A; subunit A; PR65-alpha isoform antibody; PP2A; subunit A; R1-alpha isoform antibody; PP2AAALPHA antibody; Ppp2r1a antibody; ppp2r1a-b antibody; PR65 antibody; PR65-alpha antibody; PR65A antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); alpha isoform antibody; Protein phosphatase 2 (Formerly 2A); regulatory subunit A (PR 65); alpha isoform; isoform CRA_a antibody; Protein phosphatase 2 (formerly 2A); regulatory subunit A; antibody; Protein phosphatase 2 regulatory subunit A alpha antibody; Protein phosphatase 2; 65-KD regulatory subunit A; alpha antibody; Protein phosphatase 2; regulatory subunit A; alpha isoform antibody; Protein phosphatase 2; structural/regulatory subunit A; alpha; PPP2R1A antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human PPP2R1A
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
基因功能參考文獻：
1. PP2A controls mitotic exit through EG5 dephosphorylation. PMID: 28487562
2. Total PP2A activity and PPP2R1A-associated PP2Ac activity were significantly increased in cells overexpressing PPP2R1A-WT. In addition, overexpression of PPP2R1A-WT increased cell proliferation in vitro and tumor growth in vivo PMID: 27272709
3. PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival PMID: 27469332
4. Results demonstrated that the promotive effect of eEF-2K on glycolysis resulted from the kinase-mediated restriction of synthesis of the protein phosphatase 2A-A (PP2A-A). PMID: 27181208
5. PPP2R1A mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis. PMID: 27348297
6. PPP2R1A mutations affect PP2A function and oncogenic signaling, illuminating the genetic basis for serous EC development. PMID: 27485451
7. PR65A phosphorylation regulates PP2A complex signaling. PMID: 24465463
8. Our results suggest that IH-induced ROS generation increases PP2A activation and subsequently downregulates ERK1/2 activation, which results in inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF-induced neuronal differentiation. PMID: 24885237
9. The two functional variants in PPP2R1A and PPP2R5E and their combinations are associated with lung cancer risk in the Chinese. PMID: 24204789
10. Partial unfolding of PR65/A impacts catalysis by altering the proximity of bound catalytic subunit and substrate. PMID: 24120762
11. For PPP2R1A, a heterozygous, somatic mutation (c.771G>T, p.W257C) was identified in 1 out of 37 patients (2.7%) with primary ovarian endometrioid carcinoma. PMID: 23588898
12. gene transcription of PPP2R1A regulated by the polymorphism and methylation in the promoter region PMID: 23555712
13. This study indicates that the PPP2R1A mutation occurs at a lower frequency compared to other gynecological malignancies, irrespective of the histological subtype PMID: 23267135
14. the frequent mutation of PPP2R1A in the serous type of uterine cancer, a low frequency of mutation in endometrioid endometrial cancer and absence of mutation in uterine carcinosarcoma. PMID: 21882256
15. Our findings suggest that functional genetic variants in the proximal promoter of the PP2A-Aalpha gene and their haplotypes are critical in the regulation of transcriptional activation. PMID: 21889517
16. identified somatic missense mutations in 40.8% of high-grade serous endometrial tumours and 5% of endometrial endometrioid carcinomas; mutations identified in ovarian tumours at lower frequencies;no mutations found in high- or low-grade serous carcinoma PMID: 21381030
17. PPP2R1A somatic mutations occur in certain types of uterine and ovarian neoplastic lesions, especially uterine serous carcinomas PMID: 21435433
18. PP2A-mediated dephosphorylation of Carma1 is a critical step to limit T-cell activation and effector cytokine production. PMID: 21157432
19. genes mutated in ovarian clear cell carcinoma(OCCC);data suggest PPP2R1A functions as an oncogene and ARID1A as tumor-suppressor gene; in 42 OCCCs, 7% had mutations in PPP2R1A and 57% in ARID1A; suggests aberrant chromatin remodeling contributes to OCCC PMID: 20826764
20. Data show that upon hypoxia, the TGF-beta-induced phosphorylation of Smad3 was inhibited, although Smad2 remained phosphorylated, and Smad3 was dephosphorylated by PP2A. PMID: 19951945
21. PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1 PMID: 19750005
22. Data show that DSB promote PP2A to associate with Ku 70 and Ku 86. PMID: 19794960
23. PP2A-A has a role in the failure of beta1 integrin dephosphorylation at threonines 788 and 789 in tumor cell lines PMID: 14532964
24. PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress PMID: 16717086
25. dysfunction of E-cadherin due to its endocytosis may occur in some proportion of human breast carcinomas in which the PP2A-A protein is lost or significantly reduced PMID: 16930554
26. protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax PMID: 17314097
27. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198
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相關(guān)疾病：

Mental retardation, autosomal dominant 36 (MRD36)
亞細胞定位：

Cytoplasm. Nucleus. Chromosome, centromere. Lateral cell membrane. Cell projection, dendrite.
蛋白家族：

Phosphatase 2A regulatory subunit A family
數(shù)據(jù)庫鏈接：

HGNC: 9302

OMIM: 605983

KEGG: hsa:5518

STRING: 9606.ENSP00000324804

UniGene: Hs.467192

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