PPP1R14A Antibody
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中文名稱：PPP1R14A兔多克隆抗體
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貨號：CSB-PA080007
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：17 kDa PKC-potentiated inhibitory protein of PP1 antibody; 17-KDa protein antibody; 17kDa PKC potentiated inhibitory protein of PP1 antibody; CPI 17 alpha antibody; CPI 17 antibody; CPI 17alpha antibody; CPI-17 antibody; CPI17 alpha antibody; CPI17 antibody; PKC potentiated inhibitory protein of PP1 antibody; PKC potentiated inhibitory protein of PP1, 17-KD antibody; PP14A_HUMAN antibody; PPP1INL antibody; Ppp1r14a antibody; Protein kinase C-potentiated inhibitor of protein phosphatase 1, 17-KD antibody; Protein kinase C-potentiated inhibitor protein of 17 kDa antibody; Protein phosphatase 1 antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 14A antibody; Protein phosphatase 1 regulatory subunit 14A antibody; Regulatory subunit 14A antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human CPI-17 around the non-phosphorylation site of T38.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
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基因功能參考文獻：
- CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. PMID: 27793041
- The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase. PMID: 28387646
- Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour. PMID: 27248983
- CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions PMID: 23800065
- analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells PMID: 23583905
- The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import. PMID: 23541585
- The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
- a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17. PMID: 22275376
- RACK1 may play a role in PKC/CPI-17 signaling pathway. PMID: 20875397
- cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA/Rock. PMID: 20202976
- mapped to chromosome 19q13.13-q13.2 PMID: 11931393
- CPI-17 binds directly to protein kinase C and casein kinase I. PMID: 15003508
- importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise. PMID: 15234908
- CPI-17 siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines PMID: 16885985
- These data indicate that 14,15-epoxyeicosatrienoic acid hyperpolarizes airway smooth muscle cells and relaxes precontracted human bronchi and intracellular effects are related to a PKC-dependent process involving a lower phosphorylation level of CPI-17. PMID: 17237191
- Human pregnancy is characterized by increases in PKN1 expression and PPP1R14A phosphorylation in the myometrium. PMID: 17301291
- These results are consistent with a key molecular role for CPI-17 in airway hyperresponsiveness, in the absence of bronchial wall remodeling. PMID: 18757304
- NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17. PMID: 18835652
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亞細胞定位：Cytoplasm.
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蛋白家族：PP1 inhibitor family
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組織特異性：Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
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