PPP1R13B Antibody

說明書

中文名稱：

PPP1R13B兔多克隆抗體
貨號：

CSB-PA276353
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded Human-liver, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded Human-liver, antibody was diluted at 1:100
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q96KQ4
基因名：

PPP1R13B
別名：

Apoptosis-stimulating of p53 protein 1 antibody; ASPP1_HUMAN antibody; p53BP2 like antibody; p85 antibody; Ppp1r13b antibody; Protein phosphatase 1 regulatory subunit 13B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide from Human protein at AA range: 630-680
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC,ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	IHC-p:1:50-300
ELISA	1:10000-20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
基因功能參考文獻：
1. results provide new insights into EGR-1/ASPP1 regulatory loop in sensitizing Quercetin-induced apoptosis. EGR-1/ASPP1, therefore, may be potentially used as therapeutic targets to improve cancer's response to pro-apoptosis treatments. PMID: 28594407
2. Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC. PMID: 28103919
3. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments. PMID: 26595804
4. ASPP1 and ASPP2 cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53. PMID: 23392125
5. the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 PMID: 22552744
6. ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis. PMID: 22169642
7. The ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence. PMID: 22068052
8. overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F pathway PMID: 21479363
9. Suggest that downregulation of ASPP1 by hypermethylation may be involved in the pathogenesis and progress of gestational trophoblastic disease, probably through its effect on apoptosis. PMID: 21102414
10. Data show that Lats2 and ASPP1 shunt p53 to proapoptotic promoters and promote the death of polyploid cells. PMID: 21041410
11. ASPP1 and ASPP2 genes are frequently down-regulated by DNA methylation in HBV-positive hepatocellular carcinoma, which may play important roles in the development of HCC PMID: 20034025
12. target of E2F transcription factor PMID: 15731768
13. ASPP1 CpG island aberrant methylation could be one molecular and genetic alteration in wild-type p53 tumours. PMID: 15757645
14. Mdm2 and mdmx prevent ASPP1 and ASPP2 from stimulating the apoptotic function of p53 by binding and inhibiting the transcriptional activity of p53. PMID: 15782125
15. results demonstrate that decreased expression of ASPP1 in patients with ALL is due to an abnormal methylation of its promoter and is associated with a poor prognosis PMID: 16314841
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亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear.
蛋白家族：

ASPP family
組織特異性：

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.
數據庫鏈接：

HGNC: 14950

OMIM: 606455

KEGG: hsa:23368

STRING: 9606.ENSP00000202556

UniGene: Hs.709297

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