PPFIA1 Antibody
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中文名稱：PPFIA1兔多克隆抗體
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貨號：CSB-PA618760DSR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA618760DSR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA618760DSR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PPFIA1 Polyclonal antibody
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Uniprot No.：
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基因名：PPFIA1
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別名：FLJ42630 antibody; HGNC:9245 antibody; LAR interacting protein 1 antibody; LAR-interacting protein 1 antibody; LIP 1 antibody; LIP-1 antibody; LIP.1 antibody; LIP1 antibody; LIPA1_HUMAN antibody; Liprin alpha 1 antibody; LIPRIN antibody; Liprin-alpha-1 antibody; MGC26800 antibody; PPFIA 1 antibody; PPFIA1 antibody; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1 antibody; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1 antibody; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 antibody; PTPRF interacting protein alpha 1 antibody; PTPRF-interacting protein alpha-1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Liprin-alpha-1 protein (660-800AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
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基因功能參考文獻：
- The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. PMID: 29348417
- This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. PMID: 27876801
- Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients. PMID: 28720060
- The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice. PMID: 26663347
- results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. PMID: 25492966
- Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
- PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy. PMID: 23453270
- PPFIA1 as a potential functional candidate acute lung injury risk gene PMID: 22295056
- The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
- These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy . PMID: 21157931
- Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions. PMID: 20096687
- Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage PMID: 19787783
- the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones PMID: 12923177
- liprin binds to ATP-agarose, challenged by free ATP, not by free GTP. Liprin LH region mutations inhibit liprin phosphorylation stabilized association of liprin with ATP-agarose. Suggests that liprin autophosphorylation regulates its association with LAR. PMID: 16313174
- regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
- Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, is associated with head and neck squamous cell carcinoma PMID: 18196592
- Liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion. PMID: 19690048
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亞細胞定位：Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
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蛋白家族：Liprin family, Liprin-alpha subfamily
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組織特異性：Ubiquitous.
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數據庫鏈接：
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