PPA2 Antibody

中文名稱：

PPA2兔多克隆抗體
貨號(hào)：

CSB-PA867137LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, Rat kidney tissue, Rat liver tissue, Mouse kidney tissue, Mouse liver tissue
All lanes: PPA2 antibody at 3.1µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 40, 35, 19, 26 kDa
Observed band size: 38 kDa

IHC image of CSB-PA867137LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PPA2 Polyclonal antibody
Uniprot No.：

Q9H2U2
基因名：

PPA2
別名：

HSPC124 antibody; Inorganic pyrophosphatase 2 antibody; Inorganic pyrophosphatase 2, mitochondrial antibody; IPYR2_HUMAN antibody; mitochondrial antibody; Ppa2 antibody; PPase 2 antibody; PPase2 antibody; Pyrophosphatase (inorganic) 2 antibody; Pyrophosphatase SID6 306 antibody; Pyrophosphatase SID6-306 antibody; Pyrophosphate phospho-hydrolase 2 antibody; SID6 306 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Inorganic pyrophosphatase 2, mitochondrial protein (180-298AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PPA2 Antibody (CSB-PA867137LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PPA2 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA867137LB01HU	PPA2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA867137LC01HU	PPA2 Antibody, FITC conjugated
Biotin	CSB-PA867137LD01HU	PPA2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function.
基因功能參考文獻(xiàn)：
1. findings confirm the pathogenicity of PPA2 mutations and suggest that PPA2 is a cardiomyopathy-associated protein, which has a greater physiological importance in mitochondrial function than previously recognized PMID: 27523597
2. data demonstrate that PPA2 is an essential gene in yeast and that biallelic mutations in PPA2 cause a mitochondrial disease leading to sudden cardiac arrest in infants PMID: 27523598
3. Single nucleotide polymorphisms in PPA2 is associated with response to antipsychotic agents in schizophrenia. PMID: 23241943
4. We think that PP2A can be one of the key components to regulate the fusion of various endocytotic compartments and /or the trafficking along the microtubules. PMID: 19067239
5. No pathogenic mutations were identified in the PPA2 gene in patients with mitochondrial DNA depletion syndromes (MDS). PMID: 16300924
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相關(guān)疾病：

Sudden cardiac failure, alcohol-induced (SCFAI); Sudden cardiac failure, infantile (SCFI)
亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

PPase family
組織特異性：

Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 28883

OMIM: 609988

KEGG: hsa:27068

STRING: 9606.ENSP00000343885

UniGene: Hs.654957

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