POLRMT Antibody, FITC conjugated

說明書

中文名稱：

POLRMT兔多克隆抗體, FITC偶聯
貨號：

CSB-PA018353LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POLRMT Polyclonal antibody
Uniprot No.：

O00411
基因名：

POLRMT
別名：

APOLMT antibody; DNA-directed RNA polymerase antibody; DNA-directed RNA polymerase mitochondrial antibody; h-mtRPOL antibody; mitochondrial antibody; MTRNAP antibody; MtRPOL antibody; POLRMT antibody; polymerase (RNA) mitochondrial (DNA directed) antibody; polymerase, RNA, mitochondrial antibody; RPOM antibody; RPOM_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA-directed RNA polymerase, mitochondrial protein (282-405AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand.
基因功能參考文獻：
1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined. PMID: 27436287
2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia. PMID: 26484416
3. knock-down of MRPL12 by RNA interference results in instability of POLRMT. PMID: 26586915
4. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. PMID: 26403317
5. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
6. The results demonstrate that human TFAM binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP. PMID: 24393772
7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs. PMID: 24096365
8. Authors propose that POLRMT interacts directly with h-mtTFB1 in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity. PMID: 23303773
9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension PMID: 21947009
10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII) PMID: 21799907
11. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds PMID: 21548588
12. POLRMT can function as an origin-specific primase in mammalian mitochondria. PMID: 20129056
13. human mitochondrial DNA polymerase has a role in autosomal dominant progressive external ophthalmoplegia PMID: 15258572
14. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition PMID: 15526033
15. transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV), expressed from an alternative transcript of the mitochondrial RNA polymerase gene POLRMT PMID: 16079853
16. the MRPL12 interaction with POLRMT is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation PMID: 17337445
17. Promoter-independent DNA conformation-dependent transcription required TFB2M and was suppressed by TFAM, while promoter-dependent transcription was inhibited to a lesser extent BY TFAM. PMID: 19624753
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亞細胞定位：

Mitochondrion.
蛋白家族：

Phage and mitochondrial RNA polymerase family
數據庫鏈接：

HGNC: 9200

OMIM: 601778

KEGG: hsa:5442

STRING: 9606.ENSP00000215591

UniGene: Hs.254113

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