POLR2G Antibody, Biotin conjugated

說明書

中文名稱：

POLR2G兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA018334LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POLR2G Polyclonal antibody
Uniprot No.：

P62487
基因名：

POLR2G
別名：

DNA directed RNA polymerase II 19 kDa polypeptide antibody; DNA directed RNA polymerase II subunit G antibody; DNA directed RNA polymerase II subunit RPB7 antibody; DNA-directed RNA polymerase II subunit G antibody; DNA-directed RNA polymerase II subunit RPB7 antibody; hRPB19 antibody; hsRPB7 antibody; MGC138367 antibody; MGC138369 antibody; POLR2G antibody; polymerase (RNA) II (DNA directed) polypeptide G antibody; RNA polymerase II 19 kDa subunit antibody; RNA polymerase II subunit B7 antibody; RPB19 antibody; RPB7 antibody; RPB7_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA-directed RNA polymerase II subunit RPB7 protein (1-172AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA.
基因功能參考文獻：
1. The function of Rpb7 interaction with rpb4 in human cells indicate that Rpb7 have gene-specific effects but are also more generally required for human cell survival. PMID: 23073835
2. Identification of the RNA binding region of Rpb7. PMID: 16282592
3. the emerging transcript cross-links to the Rpb7 subunit of RNA polymerase II in various complexes containing 26- to 32-nt transcripts PMID: 16327806
4. TFIIF and Rpb7 are involved in both early and late transcriptional stages PMID: 17848138
亞細胞定位：

Nucleus.
蛋白家族：

Eukaryotic RPB7/RPC8 RNA polymerase subunit family
數據庫鏈接：

HGNC: 9194

OMIM: 602013

KEGG: hsa:5436

STRING: 9606.ENSP00000301788

UniGene: Hs.14839

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