POLR2B Antibody

說明書

中文名稱：

POLR2B兔多克隆抗體
貨號：

CSB-PA018328GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P30876
基因名：

POLR2B
別名：

POLR2B antibody; DNA-directed RNA polymerase II subunit RPB2 antibody; EC 2.7.7.6 antibody; DNA-directed RNA polymerase II 140 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit B antibody; RNA polymerase II subunit 2 antibody; RNA polymerase II subunit B2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human POLR2B-Specific
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.
基因功能參考文獻：
1. Studies indicate transcription of many genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region. PMID: 21081187
2. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation PMID: 12050112
3. The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of magnesium and is required for both for the polymerization and cleavage reactions. PMID: 15886393
4. the human Maf1 protein negatively regulates transcription by all three nuclear Pols, Pol I, Pol II and Pol III PMID: 17499043
亞細胞定位：

Nucleus.
蛋白家族：

RNA polymerase beta chain family
數據庫鏈接：

HGNC: 9188

OMIM: 180661

KEGG: hsa:5431

STRING: 9606.ENSP00000312735

UniGene: Hs.602757

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