POLR1B Antibody

說明書

產品詳情

Uniprot No.：

Q9H9Y6
基因名：

POLR1B
別名：

A127 antibody; DNA directed RNA polymerase I 135kDa polypeptide antibody; DNA directed RNA polymerase I antibody; DNA directed RNA polymerase I subunit RPA2 antibody; DNA-directed RNA polymerase I 135 kDa polypeptide antibody; DNA-directed RNA polymerase I subunit rpa2 antibody; FLJ10816 antibody; FLJ21921 antibody; MGC131780 antibody; OTTHUMP00000161989 antibody; OTTHUMP00000203643 antibody; OTTHUMP00000203645 antibody; POLR 1B antibody; polr1b antibody; Polymerase (RNA) I polypeptide B 128kDa antibody; Polymerase (RNA) I polypeptide B antibody; RNA polymerase I polypeptide B antibody; RNA polymerase I subunit 2 antibody; RPA 135 antibody; RPA116 antibody; RPA135 antibody; RPA2 antibody; RPA2_HUMAN antibody; Rpo1 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human RPA135.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
基因功能參考文獻：
1. PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex PMID: 16055704
2. CK2 has the potential to regulate Pol I transcription at multiple levels, in preinitiation complex (PIC) formation, activation, and reinitiation of transcription. PMID: 16880508
3. Human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I-dependent transcription in human glioblastoma lines. PMID: 17499043
4. The average FIX expression level of the rDNA recombinants was additionally enhanced to that from a strong Pol II promoter as a result of elimination of position effects. PMID: 18194663
亞細胞定位：

Nucleus, nucleolus. Chromosome.
蛋白家族：

RNA polymerase beta chain family
數據庫鏈接：

HGNC: 20454

OMIM: 602000

KEGG: hsa:84172

STRING: 9606.ENSP00000263331

UniGene: Hs.745127

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