PNRC2 Antibody, FITC conjugated
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中文名稱：PNRC2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA018290LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PNRC2 Polyclonal antibody
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Uniprot No.：
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基因名：PNRC2
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別名：0610011E17Rik antibody; D4Bwg0593e antibody; FLJ20312 antibody; MGC11707 antibody; MGC93828 antibody; MGC99541 antibody; OTTMUSP00000010360 antibody; OTTMUSP00000010366 antibody; pnrc2 antibody; PNRC2_HUMAN antibody; Proline rich nuclear receptor coactivator 2 antibody; Proline-rich nuclear receptor coactivator 2 antibody; RP11-4M23.5 antibody; RP23-161N17.3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Proline-rich nuclear receptor coactivator 2 protein (1-139AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
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基因功能參考文獻：
- UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay. PMID: 29348139
- GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation PMID: 25775514
- PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2. PMID: 23085078
- Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
- PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex. PMID: 19150429
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亞細胞定位：Nucleus. Cytoplasm, P-body.
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蛋白家族：PNRC family, PNRC2 subfamily
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組織特異性：Expressed in heart, lung, muscle and brain.
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數據庫鏈接：
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