PNLIPRP2 Antibody, HRP conjugated

說明書

中文名稱：

PNLIPRP2兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA018264LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PNLIPRP2 Polyclonal antibody
Uniprot No.：

P54317
基因名：

PNLIPRP2
別名：

EC 3.1.1.3 antibody; Galactolipase antibody; LIPR2_HUMAN antibody; Pancreatic lipase-related protein 2 antibody; PL-RP2 antibody; PLRP2 antibody; Pnliprp2 antibody; Secretory glycoprotein GP 3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Pancreatic lipase-related protein 2 protein (305-460AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane.
基因功能參考文獻：
1. findings show that endosomal lipases participate in lipid antigen presentation by processing lipid antigens and have a role in T cell immunity against mycobacteria PMID: 27662254
2. The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 PMID: 26494624
3. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. PMID: 23732775
4. BSSL and PLRP2 hydrolyzed triglycerides (TG) to free FA and glycerol. PMID: 21865348
5. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns PMID: 21652702
6. localization of PLRP2 in endosomes of monocytes PMID: 21554982
7. Investigation of the substrate specificity of purified recombinant pancreatic lipase-related protein 2 reveals that its physiological role is digestion of galactolipids, the main plant lipids present in the vegetables which are a part of the human diet. PMID: 15287741
8. Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects. PMID: 16887271
9. finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media. PMID: 17401110
10. Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2 PMID: 18702514
11. The pancreatic lipase related protein 2 is required for lipid-dependent cytotoxicity mediated by cytotoxic T lymphocytes. PMID: 19548271
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亞細胞定位：

Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection.
蛋白家族：

AB hydrolase superfamily, Lipase family
組織特異性：

Pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 9157

OMIM: 604423

KEGG: hsa:5408

UniGene: Hs.423598

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