PLXNA2 Antibody
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中文名稱：PLXNA2兔多克隆抗體
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貨號：CSB-PA563141
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA563141(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA563141(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：PLXNA2
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別名：Plexin-A2 antibody; PlexinA2 antibody; PLXA2 antibody; PLXA2_HUMAN antibody; PLXNA2 antibody; Semaphorin receptor OCT antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human PLXNA2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
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基因功能參考文獻：
- although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
- PLXNA2 upregulation contributes to TMPRSS2:ERG-mediated enhancements of PC3c cell migration and invasion. PMID: 23708657
- PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot. PMID: 22912587
- results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling PMID: 22095611
- PLXNA2 polymorphisms show association with ankylosing spondylitis. PMID: 22011406
- in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types. PMID: 21925246
- An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene. PMID: 16402134
- results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample PMID: 17346868
- PLXNA2 confers a varying genetic risk for schizophrenia among different populations. PMID: 18065206
- Analysis of 3 SNPs at the PLXN A2 locus; we failed to replicate previously reported association of this locus and schizophrenia. PMID: 18096369
- mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling PMID: 19666519
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Plexin family
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組織特異性：Detected in fetal brain.
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數據庫鏈接：
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