PLIN4 Antibody

說(shuō)明書(shū)

中文名稱：

PLIN4兔多克隆抗體
貨號(hào)：

CSB-PA822286HA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: PLIN4 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 135, 141 kDa
Observed band size: 135 kDa

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA822286HA01HU at dilution of 1:100

Immunofluorescent analysis of PC-3 cells using CSB-PA822286HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO produces the PLIN4 antibody by immunizing rabbits with the recombinant human PLIN4 protein (308-418AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is greater than 95% using protein G purified. It only shows reactivity with human PLIN4 protein, also known as S3-12, which is highly expressed in white adipose tissue and coats lipid droplets in adipocytes to protect them from lipases. This PLIN4 antibody can be applied in ELISA, WB, IHC, and IF analyses.
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PLIN4 Polyclonal antibody
Uniprot No.：

Q96Q06
基因名：

PLIN4
別名：

Adipocyte protein S3 12 antibody; Adipocyte protein S3-12 antibody; hCG1646516 antibody; KIAA1881 antibody; Perilipin-4 antibody; Plasma membrane associated protein S3 12 antibody; Plin 4 antibody; PLIN4 antibody; PLIN4_HUMAN antibody; S3 12 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Perilipin-4 protein (308-418AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，PLIN4 Antibody (CSB-PA822286HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于PLIN4 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA822286HB01HU	PLIN4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822286HC01HU	PLIN4 Antibody, FITC conjugated
Biotin	CSB-PA822286HD01HU	PLIN4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.
基因功能參考文獻(xiàn)：
1. Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. PMID: 29626194
2. Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
3. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. PMID: 22667335
4. we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits PMID: 22210160
5. These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site PMID: 21533135
6. Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20495294
8. Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. PMID: 12840023
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亞細(xì)胞定位：

Cell membrane. Cytoplasm. Lipid droplet.
蛋白家族：

Perilipin family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 29393

OMIM: 613247

KEGG: hsa:729359

STRING: 9606.ENSP00000301286

UniGene: Hs.591387

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