PLIN3 Antibody

說明書

中文名稱：

PLIN3兔多克隆抗體
貨號：

CSB-PA954450
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA954450(PLIN3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA954450(PLIN3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

O60664
基因名：

PLIN3
別名：

47 kDa mannose 6-phosphate receptor-binding protein antibody; 47 kDa MPR binding protein antibody; 47 kDa MPR-binding protein antibody; Cargo selection protein TIP47 antibody; M6PRBP 1 antibody; M6PRBP1 antibody; Mannose 6 phosphate receptor binding protein 1 antibody; Mannose-6-phosphate receptor-binding protein 1 antibody; MGC11117 antibody; MGC2012 antibody; MPR binding protein 47 kDa antibody; Perilipin 3 antibody; Perilipin-3 antibody; Perilipin3 antibody; Placental protein 17 antibody; PLIN3 antibody; PLIN3_HUMAN antibody; pp17 antibody; Tail interacting protein 47 kD antibody; TIP47 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human PLIN3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
基因功能參考文獻：
1. High PLIN3 expression is associated with clear cell renal cell carcinoma. PMID: 29773494
2. we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq. PMID: 28893231
3. Conserved amphipathic helices mediate lipid droplet targeting of PLIN1, PLIN2, and PLIN3. PMID: 26742848
4. PLIN3 functions are intertwined with the lipogenic pathways implicated in sebaceous lipogenesis, such as desaturation and triglyceride synthesis. PMID: 25039349
5. Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages. PMID: 25595097
6. Differential expression of PLIN3 and brefeldin A sensitivity may explain differential lipid oxidation efficiency in skeletal muscle among healthy lean, sedentary, and T2 diabetic males. PMID: 26171795
7. Results indicate that microRNAs miR-148a and miR-30a, regulate Tail interacting protein of 47 kDa (TIP47) expression and lipid droplets (LD) in hepatitis C virus infected cells. PMID: 26170028
8. Following exercise training, perilipin 3 protein expression was increased in the adipose tissue of women with polycystic ovary syndrome. PMID: 25342854
9. Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. PMID: 24632837
10. Rab9-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles. PMID: 24480419
11. PLIN3 is associated with the synthesis and secretion of PGE2 PMID: 23936516
12. TIP47 plays an essential role in the life cycle of hepatitis C virus. PMID: 23354285
13. studies identified the lipid droplet(LD-associated host protein, Tail-Interacting Protein 47 (TIP47) as a novel NS5A interaction partner; data support a model where TIP47-via its interaction with NS5A-serves as a novel cofactor for HCV infection possibly by integrating LD membranes into the membranous web PMID: 23593007
14. TIP47 is here described for the first time as a viral restriction factor that acts by limiting viral protein synthesis. PMID: 23348195
15. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content in female skeletal muscle. PMID: 22667335
16. Suppression of TIP47 in HeLa cells facilitated oxidative-stress-induced cell death. PMID: 20556887
17. TIP47 is required for the encounter between Gag and Env, and thus for the generation of infectious HIV-1 particles from primary macrophages. PMID: 20070608
18. can co-localize with lipid storage proteins PMID: 12077142
19. Data show that placental protein 17b (PP17b)is a neutral lipid droplet-associated protein, and its expression is regulated by PKC- and PKA-dependent pathways PMID: 12631276
20. TIP47 binding to HIV-1 envelope glycoprotein (ENV) is required for ENV transport to the trans-golgi network and for its incorportaion into virions and its pathogenicity PMID: 12768012
21. Rab9 GTPase stability on late endosomes required interaction with TIP47 PMID: 15456905
22. TIP47 and adipophilin are components of many, but not all, the lipid droplets in THP-1 cells PMID: 15545278
23. we report the identity of an inhibitor, TIP47, which prevents retinylester hydrolysis catalyzed by GS2 lipase and hormone-sensitive lipase PMID: 16741517
24. Binding of the effector protein TIP47 is important for Rab9 localization. PMID: 16769818
25. The results suggested that the putative hydrophobic cleft is critical for the unique characteristics of TIP47. PMID: 16808905
26. These results show that TIP47 is a cellular cofactor that plays an essential role in Env incorporation, allowing the encounter and the physical association between HIV-1 Gag and Env proteins during the viral assembly process. PMID: 17003132
27. Adipophilin and TIP47 are expressed in LDs of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. PMID: 18393390
28. The present results suggest that lipid droplets (LD) and LD-associated proteins have protective effects against apoptosis induced by fatty acid-bound albumin by sequestering free fatty acids. PMID: 18832575
29. TIP47 (tail-interacting protein 47 kD) protein levels directly correlate with triglyceride levels; TIP47 may act as a carrier protein for free fatty acids and in this way participates in conversion of macrophages into foam cells PMID: 19286631
30. VV p37 protein associates with host TIP47, Rab9 and CI-MPR. PMID: 19400954
31. TIP47 has apolipoprotein-like properties and reorganizes liposomes into small lipid discs PMID: 19451273
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亞細胞定位：

Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
蛋白家族：

Perilipin family
數據庫鏈接：

HGNC: 16893

OMIM: 602702

KEGG: hsa:10226

STRING: 9606.ENSP00000221957

UniGene: Hs.140452

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