PLEKHA7 Antibody

中文名稱：

PLEKHA7兔多克隆抗體
貨號：

CSB-PA750339LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescent analysis of HepG2 cells using CSB-PA750339LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PLEKHA7 Polyclonal antibody
Uniprot No.：

Q6IQ23
基因名：

PLEKHA7
別名：

DKFZp686M22243 antibody; PH domain-containing family A member 7 antibody; PKHA7_HUMAN antibody; Pleckstrin homology domain containing family A member 2 antibody; Pleckstrin homology domain-containing family A member 7 antibody; Plekha7 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Pleckstrin homology domain-containing family A member 7 protein (294-654AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PLEKHA7 Antibody (CSB-PA750339LA01HU)，的標(biāo)記方式是Non-conjugated。對于PLEKHA7 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA750339LB01HU	PLEKHA7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA750339LC01HU	PLEKHA7 Antibody, FITC conjugated
Biotin	CSB-PA750339LD01HU	PLEKHA7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33.
基因功能參考文獻(xiàn)：
1. Downregulation of PLEKHA7 in PACG may affect BAB integrity and aqueous humor outflow via its Rac1/Cdc42 GAP activity, thereby contributing to disease etiology. PMID: 29016860
2. our findings support a multi-layered role of PLEKHA7 in converging cytoskeletal dynamics and miRNA-mediated growth regulation at the ZA, with potentially critical implications in cancer that warrant further investigation. PMID: 26822694
3. These results show that the PLEKHA7-PDZD11 complex stabilizes nectins to promote efficient early junction assembly and uncover a new molecular mechanism through which PLEKHA7 recruits PDZ-binding membrane proteins to epithelial adherens junctions. PMID: 27044745
4. Familial linkage studies for primary angle-closure glaucoma have been performed and identified PLEKHA7 causative primary glaucoma disease PMID: 26497787
5. PLEKHA7 is a junctional marker of epithelial cells within tubular structures both in normal breast tissue and ductal carcinomas PMID: 26270346
6. PLEKHA7 localization to adherens junctions is E-cadherin and p120 dependent. PMID: 26302406
7. This meta-analysis suggests that PLEKHA7 rs11024102 is associated with PACG (primary angle closure glaucoma) in Asian population and COL11A1 rs3753841 has a genetic association with the development of PACG both in Caucasian and Asian populations. PMID: 25732101
8. PLEKHA7 recruits the microprocessor complex and its core components DROSHA and DGCR8 to the zonula adherens, to suppress growth-related signaling via miRNAs PMID: 26302406
9. Specific localization of PLEKHA7 was found within PACG-related structures (iris, ciliary body, and choroid) and blood-aqueous barrier (BAB) structures (posterior iris epithelium, nonpigmented ciliary epithelium, iris and ciliary body microvasculature). PMID: 24801512
10. Our study suggests that rs1676486 and rs12138977 in COL11A1 as well as rs216489 and rs11024102 in PLEKHA7 are associated with an increased risk of PAC/PACG in the Han Chinese population PMID: 24854855
11. Axial length, anterior chamber depth and keratometry were not associated with rs3753841 or rs11024102 genotypes including after adjusting for age and sex. PMID: 23505305
12. Overexpression of PLEKHA7 is common in in-vasive lobular carcinomas and could be a molecular marker to differentiate them from invasive ductal carcinomas. PMID: 22542108
13. Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population. PMID: 21963141
14. PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin PMID: 20808826
15. PLEKHA7 binds with p120catenin and non-centrosomal minus end protein Nezha and plays a linker role between adherens junction and non-centrosomal microtubules. PMID: 19041755
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亞細(xì)胞定位：

Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
數(shù)據(jù)庫鏈接：

HGNC: 27049

OMIM: 612686

KEGG: hsa:144100

STRING: 9606.ENSP00000347883

UniGene: Hs.12332

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