PKN3 Antibody, Biotin conjugated
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中文名稱：PKN3兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA744059LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PKN3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：pkn3 antibody; PKN3_HUMAN antibody; PKNBETA antibody; Protein kinase C related kinase 3 antibody; Protein kinase N3 antibody; Protein kinase PKN beta antibody; Protein kinase PKN-beta antibody; Protein-kinase C-related kinase 3 antibody; RP11-545E17.1 antibody; Serine/threonine protein kinase N3 antibody; Serine/threonine-protein kinase N3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Serine/threonine-protein kinase N3 protein (1-252AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Contributes to invasiveness in malignant prostate cancer.
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基因功能參考文獻：
- Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors. PMID: 27919031
- PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice. PMID: 26742562
- PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics. PMID: 22609186
- PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It PMID: 21754995
- PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase PMID: 15282551
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亞細胞定位：Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region.
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蛋白家族：Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
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組織特異性：Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
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數據庫鏈接：
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