PJA2 Antibody

說明書

中文名稱：

PJA2兔多克隆抗體
貨號：

CSB-PA003792
規(guī)格：

￥1090
圖片：
Western Blot analysis of Jurkat cells using PJA2 Polyclonal Antibody

Western Blot analysis of various cells using PJA2 Polyclonal Antibody
其他：

產(chǎn)品詳情

Uniprot No.：

O43164
基因名：

PJA2
別名：

E3 ubiquitin protein ligase Praja2 antibody; E3 ubiquitin-protein ligase Praja-2 antibody; KIAA0438 antibody; Neurodap 1 antibody; Neurodap1 antibody; PJA 2 antibody; PJA2 antibody; PJA2_HUMAN antibody; Praja 2 antibody; Praja 2 RING H2 motif containing antibody; praja ring finger 2 antibody; Praja ring finger 2 E3 ubiquitin protein ligase antibody; Praja2 antibody; RING finger protein 131 antibody; RNF 131 antibody; RNF131 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human PJA2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
基因功能參考文獻：
1. Proper ubiquitin chain assembly by PJA2 requires that Tat first binds its P-TEFb cofactor. PMID: 28345603
2. The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade. PMID: 23652010
3. Detection of PJA2-FER fusion mRNA is correlated with poor postoperative survival periods in non-small cell lung cancer. PMID: 23931849
4. praja2 is a novel cancer-related gene whose expression is linked to the histotype and mutational status of the thyroid tumor. PMID: 22948757
亞細胞定位：

Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density.
數(shù)據(jù)庫鏈接：

HGNC: 17481

KEGG: hsa:9867

STRING: 9606.ENSP00000354775

UniGene: Hs.483036

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