PITX1 Antibody
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中文名稱：PITX1兔多克隆抗體
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貨號：CSB-PA018042GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PITX1
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別名：BFT antibody; CCF antibody; Hindlimb expressed homeobox protein backfoot antibody; Hindlimb-expressed homeobox protein backfoot antibody; Homeobox protein PITX1 antibody; LBNBG antibody; Paired like homeodomain 1 antibody; Paired like homeodomain transcription factor 1 antibody; Paired-like homeodomain transcription factor 1 antibody; Pituitary homeo box 1 antibody; Pituitary homeobox 1 antibody; Pituitary otx related factor antibody; Pitx1 antibody; PITX1_HUMAN antibody; POTX antibody; PTX1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PITX1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
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基因功能參考文獻：
- PITX1 might serve as a potential biomarker for early detection and prognosis prediction of patients with lung adenocarcinoma. PMID: 30322808
- As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5, during gastric carcinogenesis. PMID: 29734189
- we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in colorectal carcinoma(CRC). Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC PMID: 27752061
- Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted PMID: 29425237
- role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes PMID: 27802335
- Our results suggest that mutation of a specific loop both affects the global G4 structure and impacts the ability to interact with a G4 binding protein and small molecule ligand. PMID: 28412358
- PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma. PMID: 27742032
- PTP1B dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p120RasGAP gene expression PMID: 26840794
- To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified. (Review) PMID: 26515020
- Low PITX1 expression is associated with lung metastasis in osteosarcoma. PMID: 25936343
- We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5. PMID: 23940102
- Down-regulation of PITX1 expression might contribute to the progression of cutaneous malignant melanoma via promoting cell proliferative activity PMID: 23816528
- PITX1 regulates HIF-1a activity by binding to HIF-1b and regulatingHIF recruitment to specific target promoters. PMID: 25558831
- DUX4 gene is activated in a small number of myonuclei, the DUX4 proteins diffuse to adjacent nuclei where they activate target genes such as PITX1. PMID: 23206257
- Lienberg syndrome results from a misexpression of PITX1 in upper extremities. PMID: 23395106
- A deletion in H2AFY gene and 190,428bp of its downstream region contains a regulatory sequence that suppresses the expression of PITX1 in the upper limb buds and causes Liebenberg syndrome. PMID: 23587911
- Identified two deletions and a translocation 5' of PITX1. PMID: 23022097
- High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. PMID: 22438068
- mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly. PMID: 22258522
- These studies identify PITX1 as a new ERalpha transcriptional target. PMID: 21868451
- leukemic activation of PITX1, a novice PRD-class homeobox gene in a subset of early-staged T-ALL, which may promote leukemogenesis by inhibiting T-cell development. PMID: 21425961
- Suggest that the PITX1 polymorphism (rs479632) is not a risk factor for knee ostoearthritis susceptibility in the Chinese Han population. PMID: 20054692
- PITX1 suppresses TERT transcription through direct binding to the TERT promoter, which ultimately regulates telomerase activity PMID: 21300782
- HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. PMID: 21323949
- These findings provide evidence that c-Abl participates in modulating Pitx1 expression in the apoptotic response to DNA damage. PMID: 20563669
- SEDLIN is present in the nucleus, forms homodimers and that SEDT-associated mutations cause a loss of interaction with the transcription factors MBP1, PITX1 and SF1. PMID: 20498720
- the paired-like homeobox transcription factors Pitx1 and Pitx2 are factors functionally activating the proximal human prolactin promoter (hPRL-164luc) PMID: 12223489
- Modulation of interferon expression by co expression of hepatitis C virus NS5A protein and human homeodomain protein PTX1 PMID: 12620797
- this study represents the first demonstration for a role of pituitary homeobox 1 in the regulation of transcription of enzymes involved in adrenal steroidogenesis PMID: 12915995
- PITX1 mRNA expression is decreased in Barrett's esophagus, compared with matching normal squamous esophagus specimens, and is further decreased in Barrett's-associated cancer PMID: 16291394
- Pitx1 is expressed in normal human knee joint cartilage and its loss occurs in patients with knee osteoarthritis. PMID: 17549029
- p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene. PMID: 17762884
- up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease PMID: 17984056
- Haplotype analys. within PITX1 showed overtransmission of the A-C haplotype of markers rs11959298 - rs6596189. Individuals homozygous for the A-C haplotype risk allele were 2.54 fold more likely to be autistic than indiv. who were not carrying the allele PMID: 18053270
- Down-regulation of PITX1 may be a frequent molecular event in gastric carcinogenesis; Aberrant levels of PITX1 expression may be closely correlated with the progression and differentiation of gastric cancer PMID: 18186570
- Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation are reported. PMID: 18950742
- High BFT expression is associated with non-small cell lung cancer. PMID: 19414376
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相關疾病：Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF); Liebenberg syndrome (LBNBG)
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亞細胞定位：Nucleus.
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蛋白家族：Paired homeobox family, Bicoid subfamily
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數據庫鏈接：
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