PIP5K1B Antibody
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中文名稱：PIP5K1B兔多克隆抗體
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貨號：CSB-PA018026ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA018026ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018026ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PIP5K1B Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：MSS 4 antibody; MSS4 antibody; Phosphatidylinositol 4 phosphate 5 kinase type 1 beta antibody; Phosphatidylinositol-4-phosphate 5-kinase type I beta antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta antibody; PI4P5K 1 beta antibody; PI51B_HUMAN antibody; PIP5K1-beta antibody; PIP5K1B antibody; PIP5KIbeta antibody; Pipk 5 beta antibody; Pipk 5b antibody; Protein STM 7 antibody; Protein STM-7 antibody; PtdIns(4)P-5-kinase 1 beta antibody; STM 7 antibody; STM7 antibody; STM7 LSB antibody; Type I phosphatidylinositol 4 phosphate 5 kinase beta antibody; Type I phosphatidylinositol-4-phosphate 5-kinase beta antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 beta protein (190-470AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion.
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基因功能參考文獻：
- Data indicate that type I phosphatidylinositol 4-phosphate 5-kinase PIP5KIbeta mutants whose dimerization was impaired showed a severe decrease in PI(4,5)P2 production and plasma membrane delocalization. PMID: 25713054
- Knockdown of PIP5K1B in fibroblasts reproduced abnormal actin cytoskeleton remodeling evidenced in Friedreich's ataxia patient cells. PMID: 23552101
- Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration. PMID: 20624912
- Results identify an isoform-specific PDZ-binding motif in PIP5KIbeta, which confers specificity for PIP5KIbeta signaling at the uropod during leukocyte chemotaxis. PMID: 20442317
- findings show that the human type I phosphatidylinositol 4-phosphate 5-kinase isoform beta (PIPKIbeta) has a role in organizing signaling at the cell rear PMID: 18158329
- Syk-dependent phosphorylation of PIP5K1B is the dominant modification responsible for the decrease in cellular phosphatidylinositol 4,5-bisphosphate. PMID: 19553680
- Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283
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亞細胞定位：Cytoplasm, cytosol. Cell membrane. Endomembrane system.
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組織特異性：Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
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數據庫鏈接：
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