PIK3R6 Antibody, HRP conjugated
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中文名稱：PIK3R6兔多克隆抗體, HRP偶聯
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貨號：CSB-PA719469LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PIK3R6 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：C17orf38 antibody; Chromosome 17 open reading frame 38 antibody; HsT41028 antibody; p84 PI3K adapter protein antibody; p84 PIKAP antibody; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein antibody; p87 PI3K adapter protein antibody; p87PIKAP antibody; Phosphatidylinositol 3-kinase; regulatory subunit 6 antibody; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa antibody; Phosphoinositide 3-kinase regulatory subunit 6 antibody; PI3Kgamma adapter protein of 87 kDa antibody; PI3R6_HUMAN antibody; PIK3R6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 protein (566-667AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
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基因功能參考文獻：
- Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. PMID: 25753393
- expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
- knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization PMID: 21996737
- p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] PMID: 16476736
- ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells PMID: 18323525
- RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma PMID: 18596232
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亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein.
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數據庫鏈接：
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