PIK3R4 Antibody

中文名稱：

PIK3R4兔多克隆抗體
貨號：

CSB-PA858716LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA858716LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA858716LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA858716LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PIK3R4 Polyclonal antibody
Uniprot No.：

Q99570
基因名：

PIK3R4
別名：

MGC102700 antibody; P150 antibody; Phosphatidylinositol 3 kinase associated p150 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3 kinase adaptor protein antibody; Phosphoinositide 3 kinase regulatory subunit 4 antibody; Phosphoinositide 3 kinase regulatory subunit 4 p150 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 4 p150 antibody; Phosphoinositide 3-kinase adaptor protein antibody; Phosphoinositide 3-kinase regulatory subunit 4 antibody; PI3 kinase p150 subunit antibody; PI3-kinase p150 subunit antibody; PI3-kinase regulatory subunit 4 antibody; PI3R4_HUMAN antibody; PIK3R 4 antibody; PIK3R4 antibody; VPS 15 antibody; VPS15 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphoinositide 3-kinase regulatory subunit 4 protein (1300-1358AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PIK3R4 Antibody (CSB-PA858716LA01HU)，的標記方式是Non-conjugated。對于PIK3R4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA858716LB01HU	PIK3R4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA858716LC01HU	PIK3R4 Antibody, FITC conjugated
Biotin	CSB-PA858716LD01HU	PIK3R4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.
基因功能參考文獻：
1. A missense mutation in PIK3R4 (phosphoinositide 3-kinase regulatory subunit 4, named VPS15) in a family with a ciliopathy phenotype is identified. Besides being required for trafficking and autophagy, we show that VPS15 regulates primary cilium length in human fibroblasts. PMID: 27882921
2. Both Danon Disease and glycogen storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases PMID: 28102838
3. High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. PMID: 25840748
4. A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
5. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells PMID: 18957027
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亞細胞定位：

Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 8982

OMIM: 602610

KEGG: hsa:30849

STRING: 9606.ENSP00000349205

UniGene: Hs.149032

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