PIAS2 Antibody

說明書

中文名稱：

PIAS2兔多克隆抗體
貨號：

CSB-PA003781
規格：

￥1090
圖片：
Western Blot analysis of COS7 cells using PIASx Polyclonal Antibody

Western Blot analysis of NIH-3T3 Jurkat K562 cells using PIASx Polyclonal Antibody
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

O75928
基因名：

PIAS2
別名：

Androgen receptor interacting protein 3 antibody; Androgen receptor-interacting protein 3 antibody; ARIP3 antibody; DAB2 interacting protein antibody; DAB2-interacting protein antibody; DIP antibody; E3 SUMO protein ligase PIAS2 antibody; E3 SUMO-protein ligase PIAS2 antibody; MIZ antibody; Miz1 antibody; Msx interacting zinc finger protein antibody; Msx-interacting zinc finger protein antibody; PIAS NY protein antibody; PIAS-NY protein antibody; PIAS2 antibody; PIAS2_HUMAN antibody; PIASX antibody; PIASX-ALPHA antibody; PIASX-BETA antibody; Protein inhibitor of activated STAT x antibody; Protein inhibitor of activated STAT, 2 antibody; Protein inhibitor of activated STAT2 antibody; SIZ2 antibody; Zinc finger, MIZ-type containing 4 antibody; ZMIZ4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat,Monkey
免疫原：

Synthesized peptide derived from the N-terminal region of Human PIASx.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
基因功能參考文獻：
1. results indicated that PIAS2-mediated SUMOylation constrained HCV replication PMID: 28973998
2. These findings suggest that SUMO-1 modification of MDA5 possibly via PIAS2beta may play a role in the MDA5-mediated interferon response to viral infections. PMID: 21156324
3. PIASx may function as a co-repressor of Stat4 PMID: 12716907
4. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes PMID: 15580267
5. the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1, identifying PIASxalpha as a novel corepressor of FLI-1 PMID: 16148010
6. PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. PMID: 16713578
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亞細胞定位：

Nucleus speckle. Nucleus, PML body. Nucleus.
蛋白家族：

PIAS family
組織特異性：

Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
數據庫鏈接：

HGNC: 17311

OMIM: 603567

KEGG: hsa:9063

STRING: 9606.ENSP00000465676

UniGene: Hs.57769

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