PGM1 Antibody

中文名稱：

PGM1兔多克隆抗體
貨號：

CSB-PA017866HA01HU
規格：

￥440
圖片：
Western blot
All lanes: PGM1 antibody at 6µg/ml
Lane 1: U251 whole cell lysate
Lane 2: U937 whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 62, 64, 41 kDa
Observed band size: 62 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017866HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017866HA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA017866HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PGM1 Polyclonal antibody
Uniprot No.：

P36871
基因名：

PGM1
別名：

CDG1T antibody; Glucose phosphomutase 1 antibody; GSD14 antibody; OTTHUMP00000010519 antibody; OTTHUMP00000010520 antibody; PGM 1 antibody; PGM1 antibody; PGM1_HUMAN antibody; Phosphoglucomutase 1 antibody; Phosphoglucomutase-1 antibody; Phosphoglucomutase1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphoglucomutase-1 protein (1-562AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PGM1 Antibody (CSB-PA017866HA01HU)，的標記方式是Non-conjugated。對于PGM1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017866HB01HU	PGM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017866HC01HU	PGM1 Antibody, FITC conjugated
Biotin	CSB-PA017866HD01HU	PGM1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This enzyme participates in both the breakdown and synthesis of glucose.
基因功能參考文獻：
1. PGM1 deficiency has been recognized as a cause of the congenital disorders of glycosylation. PMID: 29858906
2. The structural perturbation resulting from mutation of this single amino acid reveals the molecular mechanism underlying PGM1 deficiency in these missense variants. PMID: 28117557
3. Homozygous mutation in the PGM1 gene is associated with PGM1 deficiency. PMID: 26768186
4. analysis of the structural basis of PGM1 enzyme dysfunction in PGM1 deficiency PMID: 26972339
5. both PGM1 protein misfolding and catalytic impairment may play a role in PGM1 deficiency PMID: 25288802
6. PGM1 is required for sustained cell growth during nutritional changes PMID: 24952355
7. Phosphoglucomutase 1 deficiency, previously identified as a glycogenosis, is also a congenital disorder of glycosylation. PMID: 24499211
8. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
9. Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP. PMID: 15522220
10. During extrauterine life, females carrying the PGM1*2 allele are relatively protected from extreme body mass increase, and during intrauterine life, PGM1*2/*2 homozygotes show a tendency to low body mass increase. PMID: 18091362
11. There is a correlation between glomerular expression of MCP-1 and PGM1 and worsening renal prognosis in paediatric lupus nephritis. PMID: 18495743
12. ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress. The impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy. PMID: 19377068
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相關疾病：

Congenital disorder of glycosylation 1T (CDG1T)
亞細胞定位：

[Isoform 1]: Cytoplasm.
蛋白家族：

Phosphohexose mutase family
數據庫鏈接：

HGNC: 8905

OMIM: 171900

KEGG: hsa:5236

UniGene: Hs.1869

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