PEX14 Antibody

說明書

中文名稱：

PEX14兔多克隆抗體
貨號：

CSB-PA017800ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017800ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PEX14 Polyclonal antibody
Uniprot No.：

O75381
基因名：

PEX14
別名：

dJ734G22.2 antibody; NAPP2 antibody; NF E2 associated polypeptide 2 antibody; Peroxin 14 antibody; Peroxin-14 antibody; Peroxisomal biogenesis factor 14 antibody; Peroxisomal membrane anchor protein PEX14 antibody; Peroxisomal membrane anchor protein Pex14p antibody; Peroxisomal membrane protein PEX14 antibody; pex14 antibody; PEX14_HUMAN antibody; Pex14p antibody; PTS1 receptor docking protein antibody; PTS1 receptor-docking protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Peroxisomal membrane protein PEX14 protein (118-377AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.
基因功能參考文獻：
1. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes. PMID: 27311714
2. PEX14 is the 13th PEX gene responsible for peroxisome biogenesis disorders. Thus far, only two patients with PEX14 deficiency have been reported. PMID: 26627464
3. The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. PMID: 24235149
4. interaction of PEX5 with catalase and PEX14 PMID: 21976670
5. PEX14 is a multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules. PMID: 21525035
6. Serves as a transcriptional corepressor in addition to its peroxisomal function. PMID: 11863372
7. peroxisomal localization of Pex14p is affected by Pex13p PMID: 14715663
8. a new complementation group of the peroxisome biogenesis disorders with PEX14 as the defective gene PMID: 15146459
9. This report represents the second PEX14-deficiency associated with Zellweger syndrome and the first documentation of a PEX14-deficient patient with detailed clinical follow-up and biochemical, morphological, and radiological data. PMID: 18285423
10. N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 and Pex19 ligand helices bind competitively to the same surface in Pex14(N) albeit with opposite directionality. PMID: 19197237
11. analysis of the human Pex5.Pex14.PTS1 protein complex structure obtained by small angle X-ray scattering PMID: 19584060
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相關疾病：

Peroxisome biogenesis disorder complementation group K (PBD-CGK); Peroxisome biogenesis disorder 13A (PBD13A)
亞細胞定位：

Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Peroxin-14 family
數據庫鏈接：

HGNC: 8856

OMIM: 601791

KEGG: hsa:5195

STRING: 9606.ENSP00000349016

UniGene: Hs.149983

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