PDLIM3 Antibody

說明書

產品詳情

Uniprot No.：

Q53GG5
基因名：

PDLIM3
別名：

Actinin associated LIM protein antibody; Actinin-associated LIM protein antibody; Alpha actinin 2 associated LIM protein antibody; Alpha-actinin-2-associated LIM protein antibody; DKFZp686L0362 antibody; Enigma homolog antibody; PDLI3_HUMAN antibody; PDLIM 3 antibody; PDLIM3 antibody; PDZ and LIM domain 3 antibody; PDZ and LIM domain protein 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PDLIM3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May play a role in the organization of actin filament arrays within muscle cells.
基因功能參考文獻：
1. This study confirmed that PDLIM3 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
2. two abnormal splicing events for actinin-associated LIM protein 3 (PDLIM3/ALP) and fibronectin 1 (FN1) in the skeletal muscles of myotonic dystrophy type 1 patients. PMID: 21549096
3. mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
4. ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line PMID: 15084604
5. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821
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亞細胞定位：

Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
組織特異性：

Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
數據庫鏈接：

HGNC: 20767

OMIM: 605889

KEGG: hsa:27295

STRING: 9606.ENSP00000284770

UniGene: Hs.701364

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