PDK3 Antibody

說明書

中文名稱：

PDK3兔多克隆抗體
貨號：

CSB-PA613585ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: PDK3 antibody at 1.6µg/ml
Lane 1: Mouse kidney tissue
Lane 2: RAW264.7 whole cell lysate
Lane 3: A431 whole cell lysate
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47, 49 kDa
Observed band size: 47 kDa

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA613585ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PDK3 Polyclonal antibody
Uniprot No.：

Q15120
基因名：

PDK3
別名：

[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial antibody; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 antibody; CMTX6 antibody; GS1-358P8.4 antibody; mitochondrial antibody; PDK3 antibody; PDK3_HUMAN antibody; Pyruvate dehydrogenase kinase isoenzyme 3 antibody; Pyruvate dehydrogenase kinase isoform 3 antibody; Pyruvate dehydrogenase kinase isozyme 3 antibody; Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial protein (137-406AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
基因功能參考文獻：
1. We have identified a p.R158H PDK3 mutation in a Korean X-linked dominant Charcot-Marie-Tooth type 6 family PMID: 26801680
2. Reduced pyruvate flux due to R158H mutant PDK3-mediated hyper-phosphorylation of the pyruvate dehydrogenase complex is the underlying pathogenic cause of peripheral neuropathy in X-linked dominant Charcot-Marie-Tooth disease. PMID: 23297365
3. Findings suggest the HIF-1/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma. PMID: 22865452
4. analysis of residues in L2 and residues in the C-terminal region and the lipoyl-binding pocket of PDK3 which are critical determinants for the cross-talk between L2 and PDK3, which up-regulates PDK3 activity PMID: 16849321
5. crystal structure of the asymmetric PDHK3/lipoyl domain 2 complex; data suggest that the asymmetric complex represents a physiological state in which binding of a single L2-domain activates one of the PDHK protomers while inactivating another PMID: 17532006
6. Distinct structural mechanisms for inhibition of PDK3 by AZD7545, dichloroacetate, and radicol. PMID: 17683942
7. increased PDK3 expression due to elevated HIF-1alpha in cancer cells may play critical roles in metabolic switch during cancer progression and chemoresistance in cancer therapy PMID: 18718909
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相關疾病：

Charcot-Marie-Tooth disease, X-linked dominant, 6 (CMTX6)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

PDK/BCKDK protein kinase family
組織特異性：

Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain.
數據庫鏈接：

HGNC: 8811

OMIM: 300905

KEGG: hsa:5165

STRING: 9606.ENSP00000387536

UniGene: Hs.296031

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