PDE8B Antibody

中文名稱：

PDE8B兔多克隆抗體
貨號：

CSB-PA529743LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA529743LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PDE8B Polyclonal antibody
Uniprot No.：

O95263
基因名：

PDE8B
別名：

3' 5' cyclic nucleotide phosphodiesterase 8B antibody; 3'5' cyclic nucleotide phosphodiesterase 8B antibody; Cell proliferation-inducing gene 22 protein antibody; FLJ11212 antibody; High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B antibody; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8B antibody; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody; HSPDE 8B antibody; HsPDE8B antibody; PDE 8B antibody; PDE8B antibody; PDE8B_HUMAN antibody; Phosphodiesterase 8B antibody; Phosphodiesterase8B antibody; PIG22 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8Bprotein (18-110AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，PDE8B Antibody (CSB-PA529743LA01HU)，的標(biāo)記方式是Non-conjugated。對于PDE8B Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA529743LB01HU	PDE8B Antibody, HRP conjugated	ELISA
FITC	CSB-PA529743LC01HU	PDE8B Antibody, FITC conjugated
Biotin	CSB-PA529743LD01HU	PDE8B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
基因功能參考文獻：
1. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis. PMID: 28382505
2. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation PMID: 28727628
3. a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration PMID: 26769607
4. Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women. PMID: 25822812
5. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism. PMID: 24497218
6. rs4704397 is associated with thyroid function, risk of MI, and body height. PMID: 23941514
7. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations PMID: 23272636
8. There is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage. PMID: 23237535
9. PDE8B gene polymorphisms may be correlated with hyperthyroxinemia in the Chinese Han population. PMID: 22781450
10. PDE8B is another PDE gene in which variations may contribute to predisposition of adrenocortical tumours. PMID: 22335482
11. In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model. PMID: 22084153
12. Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone levels. PMID: 21317282
13. Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels. PMID: 20373981
14. phosphodiesterase 8B has a role in autosomal-dominant striatal degeneration PMID: 20085714
15. selective usage of exons produces three different PDE8B variants that exhibit a tissue-specific expression pattern PMID: 12372422
16. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
17. In Alzheimer's disease brains we found that PDE8B was the only PDE isozyme showing a significant increase, in cortical areas and parts of the hippocampal formation, at Braak stages III-VI PMID: 12895443
18. PDE8B is another PDE gene linked to isolated micronodular adrenocortical disease; it is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues. PMID: 18431404
19. results suggest a primary effect of PDE8B variants on cAMP levels in the thyroid. This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PMID: 18514160
20. Genetic variation in thyroid stimulating hormone levels in pregnancy associated with the PDE8B rs4704397 genotype has implications for the number of women treated for subclinical hypothyroidism under current guidelines PMID: 19820008
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相關(guān)疾病：

Striatal degeneration, autosomal dominant 1 (ADSD1); Primary pigmented nodular adrenocortical disease 3 (PPNAD3)
蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE8 subfamily
組織特異性：

Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain
數(shù)據(jù)庫鏈接：

HGNC: 8794

OMIM: 603390

KEGG: hsa:8622

STRING: 9606.ENSP00000264917

UniGene: Hs.584830

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