PDCL3 Antibody, HRP conjugated
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中文名稱：PDCL3兔多克隆抗體, HRP偶聯
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貨號：CSB-PA872479LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PDCL3 Polyclonal antibody
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Uniprot No.：
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基因名：PDCL3
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別名：HTPHLP antibody; IAP associated factor VIAF1 antibody; MGC3062 antibody; PDCL 3 antibody; Pdcl3 antibody; PDCL3_HUMAN antibody; PHLP2A antibody; PHLP3 antibody; Phosducin like 3 antibody; Phosducin like protein 3 antibody; Phosducin-like protein 3 antibody; PhPL3 antibody; VIAF 1 antibody; VIAF antibody; VIAF-1 antibody; VIAF1 antibody; Viral IAP associated factor 1 antibody; Viral IAP-associated factor 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phosducin-like protein 3 protein (1-239AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
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基因功能參考文獻：
- results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins. PMID: 27496612
- The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2. PMID: 26059764
- data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function. PMID: 23792958
- Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. PMID: 17429077
- This publication pertains to mouse. PMID: 12424248
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亞細胞定位：Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
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蛋白家族：Phosducin family
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組織特異性：Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
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數據庫鏈接：
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