PCSK2 Antibody

中文名稱：

PCSK2兔多克隆抗體
貨號：

CSB-PA017642LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, U251 whole cell lysate, Mouse lung tissue
All lanes: Pcsk1 antibody at 8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 85 kDa
Observed band size: 85 kDa

IHC image of CSB-PA017642LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA017642LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PCSK2 Polyclonal antibody
Uniprot No.：

P16519
基因名：

PCSK2
別名：

KEX2 like endoprotease 2 antibody; KEX2-like endoprotease 2 antibody; NEC 2 antibody; NEC2 antibody; NEC2_HUMAN antibody; Neuroendocrine convertase 2 antibody; PC2 antibody; PCSK2 antibody; Prohormone convertase 2 antibody; Proprotein convertase 2 antibody; Proprotein convertase subtilisin/kexin type 2 antibody; SPC2 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Neuroendocrine convertase 2 protein (267-391AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PCSK2 Antibody (CSB-PA017642LA01HU)，的標記方式是Non-conjugated。對于PCSK2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017642LB01HU	PCSK2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017642LC01HU	PCSK2 Antibody, FITC conjugated
Biotin	CSB-PA017642LD01HU	PCSK2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
基因功能參考文獻：
1. PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes. PMID: 26607656
2. FAM20C plays a role in 7B2-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 function is regulated by alternative splicing. PMID: 25811241
3. in the processing of hypothalamic neuropeptides in huntington disease may partially arise from decreased PC1/3 and PC2 expressions. PMID: 24226266
4. variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes PMID: 23011353
5. The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population PMID: 21437630
6. differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of proprotein convertase-2 PMID: 21383526
7. PC1/3 governs the endocrine, and PC2 the neuronal processing, of proCCK, whereas PC5/6 contributes only to a modest endocrine synthesis of CCK-22. PMID: 18096669
8. SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals PMID: 20036365
9. A marked decrease in the ratio of the PC2 precursor to the total enzymatic pool is observed in the frontal cortex of Alzheimer patients; however, the content and enzymatic activity of the PC2 mature form are similar in Alzheimer patients and controls. PMID: 14614908
10. concluded that there are two novel TRE-like sequences in the hPC2 promoter and that these regions act in concert in a unique manner to facilitate the effects of thyroid hormone and 9-cis-retinoic acid on PC2 PMID: 15585599
11. Single nucleotide polymorphisms in PCSK2 is associated with type 2 diabetes PMID: 17618154
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亞細胞定位：

Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules.
蛋白家族：

Peptidase S8 family, Furin subfamily
數據庫鏈接：

HGNC: 8744

OMIM: 162151

KEGG: hsa:5126

STRING: 9606.ENSP00000262545

UniGene: Hs.315186

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