PCGF2 Antibody, HRP conjugated

說明書

中文名稱：

PCGF2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA017606LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PCGF2 Polyclonal antibody
Uniprot No.：

P35227
基因名：

PCGF2
別名：

DNA binding protein Mel 18 antibody; DNA-binding protein Mel-18 antibody; Mel 18 antibody; MGC10545 antibody; PCGF 2 antibody; PCGF2 antibody; PCGF2_HUMAN antibody; Polycomb group ring finger 2 antibody; Polycomb group RING finger protein 2 antibody; RING finger protein 110 antibody; RNF110 antibody; Zinc finger protein 144 antibody; ZNF 144 antibody; ZNF144 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Polycomb group RING finger protein 2 protein (103-316AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
基因功能參考文獻：
1. Low expression of Mel-18 is correlated with gastric cancer. PMID: 27542229
2. Mel-18 underexpression in luminal breast cancer cells caused ER-alpha downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 transactivators p53 and SP1. PMID: 25822021
3. It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression. PMID: 24964959
4. Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer. PMID: 23474752
5. PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of human APL cells. PMID: 22085718
6. these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer. PMID: 21602890
7. Loss of Mel-18 is associated with prostate cancer. PMID: 19395284
8. Our analysis showed correlation between BMI1 and PCGF2 gene's expression and survival in children with medulloblastoma. PMID: 20717685
9. Bmi-1/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy. PMID: 21162745
10. Mel-18 may serve as a useful marker in prognostic evaluation for patients with breast cancer. PMID: 20444850
11. Decreased Mel-18 and increased Bmi-1 mRNA expression was associated with the carcinogenesis and progression of gastric cancer PMID: 21059209
12. An association of Mel18 with emerin was observed in Hutchinson-Gilford progeria syndrome, but not in WT cells. PMID: 19727227
13. Mel-18 plays a significant role in the angiogenic function of endothelial cells by regulating endothelial gene expression. PMID: 20801102
14. BMI1 acts as an oncogene and Mel-18 functions as a tumor suppressor via downregulation of BMI1. PMID: 20170541
15. The oncogenic role of MEL-18 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
16. Our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc. PMID: 17151361
17. These results suggest that Bmi-1 and Mel-18 may have overlapping functions in cancer cell growth. PMID: 17452456
18. Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity. PMID: 17545584
19. Results show that a phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. PMID: 17936708
20. The results of this study strengthen the conclusion that mel-18 functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RanGAP1. PMID: 18706886
21. Single Nucleotide Polymorphism and down regulation of Mel-18 is associated with prostate cancer. PMID: 19585577
22. validated occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918
23. The mouse counterpart of this gene regulates the expression of Th2 cytokines, and plays a critical role in Th2 cell differentiation and Th-2 dependent immune responses. PMID: 11520462
24. The mouse counterpart of this gene regulates the expression of various chemokines and chemokine receptors, which may be important for T cell migration and differentiation. PMID: 11750047
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亞細胞定位：

Nucleus.
組織特異性：

Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.
數據庫鏈接：

HGNC: 12929

OMIM: 600346

KEGG: hsa:7703

STRING: 9606.ENSP00000354033

UniGene: Hs.371617

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