PATZ1 Antibody
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中文名稱：PATZ1兔多克隆抗體
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貨號：CSB-PA593186
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規(guī)格：￥1100
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圖片：
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA593186(PATZ1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PATZ1
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別名：8430401L15Rik antibody; AI447519 antibody; and zinc finger-containing protein 1 antibody; AT hook- antibody; BTB POZ domain zinc finger transcription factor antibody; BTB/POZ domain zinc finger transcription factor antibody; dJ400N23 antibody; Mazr antibody; PATZ antibody; PATZ1 antibody; PATZ1_HUMAN antibody; POZ (BTB) and AT hook containing zinc finger 1 antibody; POZ , AT hook, and zinc finger containing protein 1 antibody; POZ- antibody; Protein kinase A RI subunit alpha associated protein antibody; Protein kinase A RI subunit alpha-associated protein antibody; RIAZ antibody; Transcription factor MAZR antibody; ZBTB19 antibody; Zfp278 antibody; Zinc finger and BTB domain containing protein 19 antibody; Zinc finger and BTB domain-containing protein 19 antibody; Zinc finger protein 278 antibody; Zinc finger protein 278, isoform CRA_d antibody; Zinc finger sarcoma gene protein antibody; ZNF278 antibody; ZSG antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthetic peptide of Human PATZ1
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis. Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53. Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions.; (Microbial infection) Plays a positive role in viral cDNA synthesis.
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基因功能參考文獻(xiàn)：
- The results of IHC and qPCR analyses showed that the expression of PATZ1 in cancerous tissue was significantly lower than that in non-cancerous tissues. Meanwhile, PATZ1 expression was significantly associated with tumor differentiation and LN metastasis. PMID: 29926841
- ZNF278 played a prominent role in the pathogenesis of colorectal cancer (CRC), and promoted CRC cell proliferation via the ERK/MAPK pathway, suggesting that it may act as a potential target in the diagnosis or treatment of CRC PMID: 29039562
- this study show that PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas PMID: 27494852
- Our results suggest that PATZ1 and PP4R2 provide negative feedback on IKK/NF-kappaB signaling to prevent cancer cells from over-stimulation from cellular stimuli PMID: 27391343
- The derived allele of rs174557, which is the common variant in most populations, diminishes binding of PATZ1, a transcription factor conferring allele-specific downregulation of FADS1. PMID: 27932482
- Loss of PATZ1 expression is associated with thyroid cancer progression. PMID: 25595894
- Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation. PMID: 25755280
- these results propose that Patz1 is important for ESC pluripotency. PMID: 24380431
- The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis. PMID: 24336083
- PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging. PMID: 22052190
- these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATZ1. PMID: 20026299
- We report here the isolation and characterization of two novel nuclear BTB/POZ domain zinc finger isoformsthat are specifically expressed in early hippocampal neurons, cerebellar granule cells, and gliogenic progenitors as well as in differentiated glia PMID: 11744704
- MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF PMID: 11751862
- The results show that ZNF278 promotes cell growth, and its knockdown suppresses cell proliferation. ZNF278 could be a potential proto-oncogene in colorectal cancer. PMID: 18401526
- The short isoform of the Zinc finger Sarcoma Gene (ZSG) was isolated as a RNF4 interacting protein. PMID: 10949935
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相關(guān)疾病：A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1.
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亞細(xì)胞定位：Nucleus.
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蛋白家族：Krueppel C2H2-type zinc-finger protein family
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組織特異性：Ubiquitous.
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數(shù)據(jù)庫鏈接：
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