PARVA Antibody

說明書

中文名稱：

PARVA兔多克隆抗體
貨號：

CSB-PA017474GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9NVD7
基因名：

PARVA
別名：

Actopaxin antibody; Alpha parvin antibody; Alpha-parvin antibody; Calponin like integrin linked kinase binding protein antibody; Calponin-like integrin-linked kinase-binding protein antibody; CH ILKBP antibody; CH-ILKBP antibody; FLJ10793 antibody; FLJ12254 antibody; Matrix remodelling associated 2 antibody; Matrix remodelling associated protein 2 antibody; Matrix-remodeling-associated protein 2 antibody; MXRA 2 antibody; MXRA2 antibody; PARV A antibody; Parva antibody; PARVA_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human PARVA
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
基因功能參考文獻(xiàn)：
1. edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype PMID: 29386624
2. Protein expression of alpha-Parvin increases with colorectal cancer progression. PMID: 26115385
3. PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma PMID: 25738875
4. alpha-pv-deficient HUVECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell-extracellular matrix adhesion structures and an altered actin cytoskeleton. PMID: 25925587
5. alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma PMID: 24496929
6. Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs. PMID: 23504997
7. beta2-adaptin is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner PMID: 23056266
8. Actopaxin phosphorylation is required for matrix degradation and cell invasion via regulation of Rho GTPase signaling. PMID: 22955285
9. results also identify the integrin-linked kinase (ILK) and alpha-parvin proteins as a new molecular partner and target, respectively, of the Lnk adaptor. PMID: 22441983
10. the alpha-parvin CH2-paxillin LD1 complex has a role in focal adhesion assembly PMID: 18508764
11. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID: 11722847
12. inhibition of the ILK-alpha-parvin complex is sufficient, although not necessary, for promotion of apoptosis PMID: 15284246
13. Phosphorylation of actopaxin regulates cell spreading and migration. PMID: 15353548
14. the association between actopaxin and TESK1, which is likely regulated by phosphorylation of actopaxin, regulates TESK1 activity and subsequent cellular spreading on fibronectin PMID: 15817463
15. An unusual degree of binding degeneracy in the paxillin/alpha-parvin system that may facilitate the assembly of dynamic signaling complexes in the cell. PMID: 18940607
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亞細(xì)胞定位：

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
蛋白家族：

Parvin family
組織特異性：

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
數(shù)據(jù)庫鏈接：

HGNC: 14652

OMIM: 608120

KEGG: hsa:55742

STRING: 9606.ENSP00000334008

UniGene: Hs.432914

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