PARP3 Antibody
-
中文名稱：PARP3兔多克隆抗體
-
貨號：CSB-PA285823
-
規(guī)格：￥1100
-
圖片：
-
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA285823(PARP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA285823(PARP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
-
-
其他：
產(chǎn)品詳情
-
Uniprot No.：
-
基因名：
-
別名：ADP ribosyltransferase (NAD+, poly (ADP ribose) antibody; ADP ribosyltransferase diphtheria toxin like 3 antibody; ADPRT-3 antibody; ADPRT3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD3 antibody; hPARP 3 antibody; hPARP-3 antibody; hPARP3 antibody; IRT 1 antibody; IRT1 antibody; NAD(+) ADP ribosyltransferase 3 antibody; NAD(+) ADP-ribosyltransferase 3 antibody; NAD+ ADP ribosyltransferase 3 antibody; pADPRT 3 antibody; pADPRT-3 antibody; pADPRT3 antibody; PARP 3 antibody; PARP-3 antibody; PARP3 antibody; PARP3_HUMAN antibody; Poly (ADP ribose) polymerase family, member 3 antibody; Poly (ADP ribose) synthetase 3 antibody; Poly [ADP-ribose] polymerase 3 antibody; Poly[ADP ribose] synthetase 3 antibody; Poly[ADP-ribose] synthase 3 antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human
-
免疫原：Fusion protein of Human PARP3
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：Antigen affinity purification
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
-
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA,IHC
-
推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
-
功能：Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin.
-
基因功能參考文獻：
- These data identify PARP3 as a molecular sensor of nicked nucleosomes. PMID: 27530147
- PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
- Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends. PMID: 29054115
- In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
- we found that PARP3 interacted with FoxM1 to enhance its transcriptional activity and conferred glioblastoma cell radioresistance. Thus, our data suggest that PARP3 could be a therapeutic target to overcome radioresistance in glioblastoma PMID: 26040766
- Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed. PMID: 25800440
- MiR-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4, and EP300. PMID: 25255219
- In some cancer cells, repression of PARP3 could be responsible for an increased telomerase activity. PMID: 24528514
- PARP3 likely facilitates the recruitment of Ku80 to double strand breaks to antagonize DNA end resection but facilitate Ku-mediated accurate classical non-homologous end-joining. PMID: 24598253
- PARP3 gene occupancy in the human neuroblastoma cell line SK-N-SH occurs preferentially with developmental genes regulating cell fate specification, tissue patterning, craniofacial development and neurogenesis. PMID: 21264220
- PARP3 is a critical player in the stabilization of the mitotic spindle and in telomere integrity by associating and regulating the mitotic components NuMA and tankyrase 1. PMID: 21270334
- PARP-3 has a role in chromosomal DNA double-strand break repair. PMID: 21211721
- the interaction between PARP-1 and PARP-3 is unrelated to DNA single-strand break repair PMID: 20064938
- PARP-3 is a nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage PMID: 16924674
顯示更多
收起更多
-
亞細胞定位：Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
-
組織特異性：Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
-
VDAC1 Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human, Mouse, Rat
