PAPSS1 Antibody
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中文名稱：PAPSS1兔多克隆抗體
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貨號：CSB-PA203103
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA203103(PAPSS1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA203103(PAPSS1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PAPSS1
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別名：3 prime phosphoadenosine 5 prime phosphosulfate synthase 1 antibody; 3' phosphoadenosine 5' phosphosulfate synthase 1 antibody; 3''-phosphoadenosine-5''-phosphosulfate synthase antibody; Adenosine-5''-phosphosulfate 3''-phosphotransferase antibody; Adenylyl-sulfate kinase antibody; Adenylylsulfate 3''-phosphotransferase antibody; APS kinase antibody; ATP-sulfurylase antibody; ATPSK 1 antibody; ATPSK1 antibody; ATPSK2 antibody; Bifunctional 3' phosphoadenosine 5' phosphosulfate synthetase 1 antibody; PAPS synthase 1 antibody; PAPS synthetase 1 antibody; PAPS1_HUMAN antibody; PAPSS 1 antibody; PAPSS antibody; PAPSS1 antibody; SAT antibody; SK 1 antibody; SK1 antibody; SK2 antibody; Sulfate adenylate transferase antibody; Sulfurylase kinase 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human PAPSS1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.
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基因功能參考文獻：
- These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes PMID: 28790117
- we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca(2+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. PMID: 27941888
- leptin signalling links a novel SFK/ERK1/2-mediated pathway and SK1 expression. PMID: 25482303
- SK1 positivity and high expression were significantly associated with cancer and a shorter 5-year and overall survival. PMID: 24587339
- study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis PMID: 22380844
- SK1 plays an essential role in regulating in vitro paracrine angiogenesis and lymphangiogenesis. PMID: 20335228
- characterization and expression of bifunctional isoforms PMID: 11931637
- review of PAPSS biochemistry, molecular biology and genetics PMID: 12716056
- x-ray crystallographic analysis of 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 PMID: 14747722
- The kinetic characteristics of the individual sulfurylase and kinase activities of PAPSS isoform 1, the predominant form in human brain, are described. PMID: 15065880
- Results describe the crystal structure of human PAPSS1 at 1.8 angstroms resolution. PMID: 15755455
- ATP-sulfurylase domain of PAPS synthetase influences these elements in adenylylsulfate kinase, which may be a mechanism between both domains the this bifunctional enzyme PMID: 17540769
- a role for PAPSS1 in the cellular sulfonation pathway requirement at a stage during or shortly after MLV provirus establishment, and subsequent influence on gene expression from the viral long terminal repeat promoter PMID: 19008949
- PAPSS1 maps to chromosome 4q25 and may havea role in hepatocellular carcinoma PMID: 19337310
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蛋白家族：APS kinase family; Sulfate adenylyltransferase family
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組織特異性：Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
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