PAK3 (Ab-154) Antibody

說明書

中文名稱：

PAK3 (Ab-154)兔多克隆抗體
貨號：

CSB-PA554964
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from rat heart, using PAK3 (Ab-154) antibody.

Western blot analysis of extracts from HeLa cells (Lane 2), using PAK3 (Ab-154) antiobdy. The lane on the left is treated with systhesized peptide.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PAK3 Polyclonal antibody
Uniprot No.：

O75914
基因名：

PAK3
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized non-phosphopeptide derived from Human PAK3 around the phosphorylation site of serine 154 (Y-M-S(p)-F-T).
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
基因功能參考文獻：
1. The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. PMID: 29169729
2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
3. This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
4. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. PMID: 25666757
5. Cdc42Hs binds to the effector domain of PAK3 PMID: 25109462
6. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
7. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
8. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid PMID: 20960100
9. PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. The MRX30 mutation might contribute to the cognitive deficits underlying this form of X-linked mental retardation. PMID: 15574732
10. PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. PMID: 18523455
11. PAK3 codes for a splice variant that contains a 45-bp alternatively spliced exon. The exon encodes 15 aa that are inserted in the regulatory domain. PAK3b displays a high kinase activity in starved cells that is not further stimulated by active GTPases. PMID: 12464619
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相關(guān)疾病：

Mental retardation, X-linked 30 (MRX30)
亞細胞定位：

Cytoplasm.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
數(shù)據(jù)庫鏈接：

HGNC: 8592

OMIM: 300142

KEGG: hsa:5063

STRING: 9606.ENSP00000353864

UniGene: Hs.593599

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