PAFAH1B2 Antibody

說明書

中文名稱：

PAFAH1B2兔多克隆抗體
貨號：

CSB-PA017384GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P68402
基因名：

PAFAH1B2
別名：

Intracellular platelet activating factor acetylhydrolase alpha 2 subunit antibody; PA1B2_HUMAN antibody; PAF acetylhydrolase 30 kDa subunit antibody; PAF AH 30 kDa subunit antibody; PAF AH beta subunit antibody; PAF AH subunit beta antibody; PAF-AH 30 kDa subunit antibody; PAF-AH subunit beta antibody; PAFAH 30 kDa subunit antibody; PAFAH beta subunit antibody; PAFAH subunit beta antibody; Pafah1b2 antibody; PAFAH1B2 protein antibody; PAFAHB antibody; Platelet activating factor acetylhydrolase 1b catalytic subunit 2 antibody; Platelet activating factor acetylhydrolase IB beta subunit antibody; Platelet activating factor acetylhydrolase IB subunit beta antibody; Platelet activating factor acetylhydrolase isoform Ib beta subunit antibody; Platelet activating factor acetylhydrolase isoform Ib subunit 2 antibody; Platelet-activating factor acetylhydrolase IB subunit beta antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PAFAH1B2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
基因功能參考文獻：
1. PAF is demonstrated to be the key indicator in the lipid metabolism of polypoidal choroidal vasculopathy patients in this study. PMID: 27910906
2. PAFAH1B2 and 1B3 are important in maintaining cancer pathogenicity across a wide spectrum of cancer types. PMID: 25945974
3. The R92H and I198T polymorphisms are highly related to the plasma PAF-AH levels and the risk of coronary heart disease, especially among patients with blood stasis syndrome. PMID: 25034894
4. aspirin is hydrolyzed in plasma by two enzymes, BChE and a new extracellular form of platelet-activating factor acetylhydrolase, PAFAH1b2. PMID: 23508960
5. Knockdown of PAFAH1B2 strongly reduced Abeta secretion from human cells, and this effect was confirmed in primary cells derived from PAFAH1B2 knock-out mice PMID: 23238734
6. Plasma PAF-AH can hydrolyze oxidized phospholipids, and may attenuate the spreading of lipid peroxidation and participate in defense mechanisms against vasospasm after aneurysmal subarachnoid hemorrhage. PMID: 21866060
7. intracellular type I PAF acetylhydrolase (PAFAH1B2 and PAFAH1B3) is the major aspirin hydrolase of human blood PMID: 21844189
8. PAFAH1B2 is not the gene responsible for the linkage evidence on chromosome 11q23 in protein C deficiency. PMID: 17849047
9. splice variants of the Pafah1b2 gene transcript retain exons 1-5 and replace exon 6 with alternative exons derived from genomic sequence 3' to exon 6. Splice variants encode two proteins with different novel carboxy termini PMID: 18155631
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亞細胞定位：

Cytoplasm.
蛋白家族：

'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 8575

OMIM: 602508

KEGG: hsa:5049

STRING: 9606.ENSP00000435289

UniGene: Hs.728488

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