PADI1 Antibody, HRP conjugated
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中文名稱：PADI1兔多克隆抗體, HRP偶聯
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貨號：CSB-PA891543LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PADI1 Polyclonal antibody
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Uniprot No.：
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基因名：PADI1
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別名：HPAD10 antibody; Padi1 antibody; PADI1_HUMAN antibody; PDI antibody; PDI1 antibody; Peptidylarginine deiminase I antibody; protein arginine deiminase type I antibody; Protein-arginine deiminase type I antibody; Protein-arginine deiminase type-1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Protein-arginine deiminase type-1 protein (1-663AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the deimination of arginine residues of proteins.
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基因功能參考文獻：
- Authors showed that PAD1 interacts with and citrullinates MEK1 thereby disrupting MEK1-catalyzed ERK1/2 phosphorylation, thus leading to the MMP2 overexpression. PMID: 28844713
- Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination. PMID: 26616205
- NF-kappaB-mediated signaling pathway is involved in PADI1 regulation in human epidermal keratinocytes PMID: 20596086
- cloning, gene organization, and expression analysis PMID: 12416996
- peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13 PMID: 15150696
- PAD1 and 3 are able to modify filaggrin PMID: 15675958
- PAD1 is co-located with filaggrin within the filamentous matrix of the deeper corneocytes where the protein is deiminated. PMID: 16091842
- MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
- The expressoin of COL1A1-PADI1 genes were particularly effective in distinguishing OCSS from normal tissue. PMID: 18669583
- peptidylarginine deiminase citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation PMID: 18710930
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亞細胞定位：Cytoplasm.
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蛋白家族：Protein arginine deiminase family
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組織特異性：Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.
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數據庫鏈接：
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