PA2G4 Antibody
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中文名稱：PA2G4兔多克隆抗體
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貨號(hào)：CSB-PA017344GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：PA2G4
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別名：38kDa antibody; AA672939 antibody; Cell cycle protein p38 2G4 homolog antibody; Cell cycle protein p38-2G4 homolog antibody; ErbB-3 binding protein 1 antibody; ErbB3 binding protein 1 antibody; ErbB3-binding protein 1 antibody; ErbB3-binding protein Ebp1 antibody; hG4 1 antibody; hG4-1 antibody; IRES-specific cellular trans-acting factor 45 kDa antibody; MGC81621 antibody; MGC94070 antibody; Mpp1 antibody; p38 2G4 antibody; Pa2g4 antibody; PA2G4_HUMAN antibody; Plfap antibody; Proliferation associated 2G4 antibody; Proliferation associated 2G4; 38-KD antibody; Proliferation-associated 2G4; 38kDa antibody; Proliferation-associated 2G4; a antibody; Proliferation-associated protein 1 antibody; Proliferation-associated protein 2G4 antibody; Protein p38-2G4 antibody; si:dz150i12.2 antibody; wu:fb19b11 antibody; wu:ft56d05 antibody; zgc:86732 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human PA2G4
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.
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基因功能參考文獻(xiàn)：
- Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. PMID: 30224479
- In this study, the authors demonstrated that overexpression of ErbB3-binding protein 1 (EBP1) promoted not only a reduction of wild type of p85 subunit of phosphoinositide 3-kinase but also oncogenic mutant forms of p85 which were identified in human cancers. PMID: 27464702
- The results demonstrate an important role of Ebp1 in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen expression. PMID: 26813358
- results show that EBP1 interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus. PMID: 27118868
- The adapter function of EBP1 P42 stabilized the interaction of FBXW7 with its substrates and promoted FBXW7-mediated degradation of oncogenic targets, enhancing its overall tumor-suppressing function. Results establish distinct physical and functional interactions between FBXW7 and EBP1 isoforms, which yield their mechanistically unique isoform-specific functions of EBP1 in cancer. PMID: 28209614
- The combined determination of Ebp1 and p53 expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis. PMID: 26436510
- Data highlight the tissue specificity function of EBP1 isoforms and show that only the oncogene p48 activates MHC II expression in human solid tumors, via STAT1 phosphorylation, in order to affect tumor progression by triggering specific immune response. PMID: 26081906
- Our results suggest a novel function of Ebp1 as a binding protein and negative regulator of Anxa2. The functional association between Anxa2 and EBP1 may participate in regulating cancer cell proliferation and invasion, contributing to cancer progression. PMID: 25917452
- Ebp1 functionality is independent from heat-shock-protein-regulated progression networks in prostate cancer. PMID: 24798454
- P48Ebp1 acts as an oncoprotein. PMID: 25154617
- EBP1 participates in the regulation of intestinal inflammation via mediating Akt signaling pathway. PMID: 26256794
- Data suggest that inhibiting ErbB3-binding protein 1 Ebp1 phosphorylation may be an effective mechanism for inhibiting T-cell activation and proliferation. PMID: 25691158
- Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. PMID: 24651434
- data suggest that Vpr may inhibit Ebp1 to stabilize p53, which in turn leads to G2 arrest and apoptosis in U87MG cells PMID: 23828502
- identified among endothelial antigens to which antibodies are produced during heart transplant rejection PMID: 23707440
- The major effect of EBP1 on ErbB2 mRNA expression levels is at the transcriptional level. PMID: 23242156
- Down-regulation of the ErbB3 binding protein 1 in human bladder cancer promotes tumor progression and cell proliferation. PMID: 23283744
- Performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues.The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. PMID: 23110497
- It was shown that high level of Ebp1 expression led to enhancee HDM2 phosphorylation by Akt and inhibited the self-ubiquitination of HDM2 by up-regulation of Akt activity. PMID: 21930127
- the Ebp1 promoter localizes between -664 nt and the initiation site of the Ebp1 gene, +317-nt long sequence in the noncoding region is required for regulation of Ebp1 gene expression. PMID: 21794029
- These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in castration-resistant prostate cancer. PMID: 21965718
- Ebp1 contributes to neuronal cell differentiation and growth factor specificity through the activation of protein kinase Cdelta acting as a crucial downstream effector of neurotrophin signaling. PMID: 21145366
- Ablation of EBP1 expression led to tamoxifen resistance in breast cancer. PMID: 20379846
- Data show that E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context. PMID: 21085677
- Findings suggest that eBP1 p48 functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to p53 downregulation. PMID: 21098709
- our results reveal an EBP1-Foxa-AGR2 signaling circuit with functional significance in metastatic prostate cancer PMID: 20048076
- EBP1 is in the cytoplasm & nucleolus. Nucleolar localization requires AA sequences at the NH2- and COOH-ends. Overexpression inhibits proliferation of human fibroblasts. It is part of RNP complexes & associates with different rRNAs. PMID: 15064750
- ErbB3-binding protein Ebp1 binding to E2F promoter elements and E2F-mediated transcription are regulated by heregulin. PMID: 15073182
- These studies suggest that Ebp1 is an AR corepressor whose biological activity can be regulated by the ErbB3 ligand, HRG. PMID: 15583694
- Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. PMID: 15994225
- Ebp1 is present in protein-ARE(bcl-2) RNA complexes. Ebp1 & nucleolin are present in the same bcl-2 mRNP complexes. Ebp1 decreases the rate of decay of beta-globin-ARE(bcl-2) transcripts. Ebp1 contributes to bcl-2 expression regulation in HL-60 cells. PMID: 16396631
- Our results demonstrate that Ebp1 is a new dsRNA-binding protein that acts as a cellular inhibitor of eIF2alpha phosphorylation suggesting that it could be involved in protein translation control PMID: 16631606
- over-expression of Ebp1 interfered with virus production PMID: 17295834
- PKC-delta antagonizes apoptosis through phosphorylating Ebp1 and protects it from apoptotic degradation. PMID: 17316401
- ErbB-3-binding protein-1 is an immunogenic protein with cancer-related immunoreactivity, capable of eliciting CD8-positive T cell-mediated responses in vivo and in vitro. PMID: 17641068
- The structure provides insights in how Ebp1 discriminates between its different interaction partners. PMID: 17765895
- ErbB-3-binding protein 1 (Ebp1) is a member of the family of proliferation-associated 2G4 proteins (PA2G4s) and plays a role in cellular growth and differentiation. PMID: 17768350
- These results suggest that EBP1, by down-regulating ErbB signal transduction, attentuates HRG-mediated growth of breast cancer cells. PMID: 18355957
- These data support a role for EBP1 in the development of hormone-refractory prostate cancer. PMID: 18852121
- hBre1 inhibits Ebp1's tumor suppressive activity through mediating its polyubiquitination and degradation. PMID: 19037095
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亞細(xì)胞定位：[Isoform 1]: Cytoplasm. Nucleus, nucleolus.; [Isoform 2]: Cytoplasm.
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蛋白家族：Peptidase M24 family
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組織特異性：Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver.
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