OSCAR Antibody

中文名稱：

OSCAR兔多克隆抗體
貨號：

CSB-PA811628OA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: THP-1 whole cell lysate, HL60 whole cell lysate
All lanes: OSCAR antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 31, 29, 30, 28 kDa
Observed band size: 31 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) OSCAR Polyclonal antibody
Uniprot No.：

Q8IYS5
基因名：

OSCAR
別名：

OSCAR antibody; Osteoclast-associated immunoglobulin-like receptor antibody; Osteoclast-associated receptor antibody; hOSCAR antibody; Polymeric immunoglobulin receptor 3 antibody; PIgR-3 antibody; PIgR3 antibody; Poly-Ig receptor 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Osteoclast-associated immunoglobulin-like receptor protein (265-279AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，OSCAR Antibody (CSB-PA811628OA01HU)，的標記方式是Non-conjugated。對于OSCAR Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA811628OB01HU	OSCAR Antibody, HRP conjugated	ELISA
FITC	CSB-PA811628OC01HU	OSCAR Antibody, FITC conjugated
Biotin	CSB-PA811628OD01HU	OSCAR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
基因功能參考文獻：
1. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts PMID: 28555364
2. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis. PMID: 26786702
3. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1. PMID: 26552697
4. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. PMID: 25716998
5. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients. PMID: 23146195
6. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA. PMID: 24448348
7. Rotative stress in mouse cells results in increased levels of Oscar transcription. PMID: 22949349
8. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion. PMID: 22985931
9. OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 PMID: 22009730
10. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
11. This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases. PMID: 21172874
12. hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response. PMID: 15155468
13. ligation of OSCAR promotes dendritic cell survival by an ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules PMID: 15650060
14. Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j receptor. PMID: 15905516
15. Promoter variant in OSCAR gene (OSCAR-2322A>G) might be one of genetic determinants of bone density in postmenopausal women. PMID: 16007331
16. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
17. OSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses. PMID: 16493074
18. OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation PMID: 18821671
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亞細胞定位：

[Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
數據庫鏈接：

HGNC: 29960

OMIM: 606862

KEGG: hsa:126014

STRING: 9606.ENSP00000352671

UniGene: Hs.347655

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