ORC6 Antibody
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中文名稱：ORC6兔多克隆抗體
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貨號：CSB-PA017236GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：ORC 6 antibody; Orc6 antibody; ORC6_HUMAN antibody; ORC6L antibody; Origin recognition complex subunit 6 antibody; origin recognition complex subunit 6 homolog like antibody; origin recognition complex subunit 6 homolog like (yeast) antibody; origin recognition complex subunit 6 like (yeast) antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ORC6L
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
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基因功能參考文獻：
- The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. PMID: 28186598
- The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. PMID: 25691413
- our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions PMID: 24137536
- findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. PMID: 21461783
- Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PMID: 21502537
- results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis PMID: 12169736
- Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
- Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin PMID: 19112505
- In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. PMID: 19541634
- Functional studies of the Drosophila homolog PMID: 11593009
- Functional studies of the yeast homolog PMID: 8266075
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相關疾病：Meier-Gorlin syndrome 3 (MGORS3)
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亞細胞定位：Nucleus.
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蛋白家族：ORC6 family
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數據庫鏈接：
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