OPLAH Antibody

說明書

產品詳情

Uniprot No.：

O14841
基因名：

OPLAH
別名：

5 Opase antibody; 5 oxo L prolinase antibody; 5 oxoprolinase (ATP hydrolysing) antibody; 5 oxoprolinase antibody; 5-OPase antibody; 5-oxo-L-prolinase antibody; 5-oxoprolinase antibody; DKFZp434H244 antibody; OPLA antibody; OPLA_HUMAN antibody; oplah antibody; OPLAHD antibody; Pyroglutamase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human OPLAH
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
基因功能參考文獻：
1. An autosomal recessive mode of inheritance for 5-oxoprolinase deficiency is further supported by the identification of a single mutation in all 9/14 parent sample sets investigated (except for the father of one patient whose result suggests homozygosity), and the absence of 5-oxoprolinuria in all tested heterozygotes PMID: 27477828
2. In this study, clinical, biochemical, and genetic aspects of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene mutations were investigated. PMID: 25851806
3. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase PMID: 20413906
相關疾病：

5-oxoprolinase deficiency (OPLAHD)
蛋白家族：

Oxoprolinase family
數(shù)據(jù)庫鏈接：

HGNC: 8149

OMIM: 260005

KEGG: hsa:26873

UniGene: Hs.305882

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