OGDH Antibody
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中文名稱：OGDH兔多克隆抗體
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貨號：CSB-PA016307GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：OGDH
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別名：2 oxoglutarate dehydrogenase antibody; 2 oxoglutarate dehydrogenase complex component E1 antibody; 2 oxoglutarate dehydrogenase mitochondrial antibody; 2-oxoglutarate dehydrogenase antibody; 2-oxoglutarate dehydrogenase complex component E1 antibody; AKGDH antibody; Alpha ketoglutarate dehydrogenase antibody; Alpha-ketoglutarate dehydrogenase antibody; E1k antibody; mitochondrial antibody; ODO1_HUMAN antibody; OGDC antibody; OGDC E1 antibody; OGDC-E1 antibody; OGDH antibody; Oxoglutarate (alpha ketoglutarate) dehydrogenase (lipoamide) antibody; Oxoglutarate decarboxylase antibody; Oxoglutarate dehydrogenase (lipoamide) antibody; Oxoglutarate dehydrogenase (succinyl transferring) antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human OGDH
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
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基因功能參考文獻：
- PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH). PMID: 28396387
- oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1alpha in a non-hydroxylated form. PMID: 27923773
- Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types PMID: 26936970
- ATP consumption is demonstrated in respiration-impaired isolated mice and in situ neuronal mitochondria from transgenic mice with dihydrolipoyl succinyltransferase deficiency. PMID: 23475850
- Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium. PMID: 22169199
- Differences in oxoglutarate dehydrogenase activity suggest that there is no excess mitochondrial capacity during maximal exercise with a small muscle mass. PMID: 21611730
- 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah PMID: 15466852
- Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. PMID: 15649899
- Association with autosomal recessive DOOR syndrome not found. PMID: 17343268
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亞細胞定位：Mitochondrion matrix. Nucleus.
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蛋白家族：Alpha-ketoglutarate dehydrogenase family
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數(shù)據(jù)庫鏈接：
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